Gly-Pro-Arg-Pro

Discontinued Product

Unfortunately Gly-Pro-Arg-Pro (Cat. No. 1805) has been withdrawn from sale for commercial reasons.
Cat.No. 1805 - Gly-Pro-Arg-Pro | Gly-Pro-Arg-Pro | CAS No. 67869-62-9
Description: Inhibits fibrin polymerization
Alternative Names: Anti-polymerant peptide, GPRP
Datasheet
Citations
Literature

Biological Activity

Inhibitor of fibrin polymerization; binds to fibrinogen (Ki = 400 mM). Anticoagulant.

Technical Data

M. Wt 425.49
Formula C18H31N7O5
Sequence GPRP
Storage Desiccate at -20°C
CAS Number 67869-62-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 425.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.75 mL 23.5 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.24 mL 1.18 mL 2.35 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hsieh et al (1981) Fibrin polymerization. 1. Alkylating peptide inhibitors of fibrin polymerization. J.Med.Chem. 24 322 PMID: 7265118

Laudano and Doolittle (1980) Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences. Biochemistry 19 1013 PMID: 7356959

Laudano and Doolittle (1978) Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers Proc.Natl.Acad.Sci.U.S.A. 75 3085 PMID: 277910

Keywords: Gly-Pro-Arg-Pro, supplier, inhibitors, inhibits, fibrin, polymerization, Glycoprotein, IIb/IIIa, αIIbα3, alphaIIbalpha3, E, Selectin, ICAM, NCAM, P-Selectin, Laminin, Annexin, Lipocortin, 1, Selectins, Adhesion, Molecules, Anti-polymerant, peptide, GPRP, Cell, Adhesion, Molecules, Tocris Bioscience

Citations for Gly-Pro-Arg-Pro

Citations are publications that use Tocris products.

Currently there are no citations for Gly-Pro-Arg-Pro.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Gly-Pro-Arg-Pro

Protocols

TODO: Add Protocols