GLPG 0974

Pricing Availability   Qty
Cat.No. 5621 - GLPG 0974 | C25H25ClN2O4S | CAS No. 1391076-61-1
Description: Potent FFA2 antagonist
Chemical Name: 4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent FFA2 antagonist (IC50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable.

Technical Data

M. Wt 485
Formula C25H25ClN2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1391076-61-1
PubChem ID 57520598
InChI Key MPMKMQHJHDHPBE-RUZDIDTESA-N
Smiles O=C(N1[C@](C(N(CC2=CC(Cl)=CC=C2)CCCC(O)=O)=O)(C)CC1)C3=CSC4=C3C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.5 100
1eq. NaOH 9.7 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 485. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.31 mL 20.62 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Pizzonero et al (2014) Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J.Med.Chem. 57 10044 PMID: 25380412


If you know of a relevant reference for GLPG 0974, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Free Fatty Acid Receptor Antagonists

Keywords: GLPG 0974, GLPG 0974 supplier, GLPG0974, free, fatty, acid, receptors, FFA2, antagonists, antagonism, potent, Free, Fatty, Acid, Receptors, 5621, Tocris Bioscience

Citations for GLPG 0974

Citations are publications that use Tocris products.

Currently there are no citations for GLPG 0974. Do you know of a great paper that uses GLPG 0974 from Tocris? Please let us know.

Reviews for GLPG 0974

There are currently no reviews for this product. Be the first to review GLPG 0974 and earn rewards!

Have you used GLPG 0974?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling