Ginkgolide B

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Cat.No. 1657 - Ginkgolide B | C20H24O10 | CAS No. 15291-77-7
Description: PAF receptor antagonist
Alternative Names: BN 52021
Chemical Name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
Citations (1)
Literature (3)

Biological Activity for Ginkgolide B

Ginkgolide B is a platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.

Technical Data for Ginkgolide B

M. Wt 424.4
Formula C20H24O10
Storage Desiccate at +4°C
CAS Number 15291-77-7
PubChem ID 10971931
Smiles O=C1[C@@H](C)[C@@]2(O)[C@@]([C@H](O)C34[C@]52O[C@@]6([H])[C@]([C@@H](O)C(O6)=O)3[C@H]([C@](C)(C)C)C[C@H]4O[C@]5=O)([H])O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ginkgolide B

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.44 100
ethanol 10.61 25

Preparing Stock Solutions for Ginkgolide B

The following data is based on the product molecular weight 424.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.78 mL 23.56 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References for Ginkgolide B

References are publications that support the biological activity of the product.

Desquand et al (1986) Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. Eur.J.Pharmacol. 127 83 PMID: 3019727

Foldes-Filep et al (1987) Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. Biochem.Biophys.Res.Commun. 148 1412 PMID: 2825685

Maclennan et al (2002) The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog.Neurobiol. 67 235 PMID: 12169298

If you know of a relevant reference for Ginkgolide B, please let us know.

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Keywords: Ginkgolide B, Ginkgolide B supplier, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, GinkgolideB, BN52021, BN, 52021, (PAF), 1657, Tocris Bioscience

1 Citation for Ginkgolide B

Citations are publications that use Tocris products. Selected citations for Ginkgolide B include:

Huang et al (2015) Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. Nat Neurosci 15 50 PMID: 25956877

Do you know of a great paper that uses Ginkgolide B from Tocris? Please let us know.

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Literature in this Area

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