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Platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 424.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.36 mL||11.78 mL||23.56 mL|
|5 mM||0.47 mL||2.36 mL||4.71 mL|
|10 mM||0.24 mL||1.18 mL||2.36 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
References are publications that support the biological activity of the product.
Desquand et al (1986) Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. Eur.J.Pharmacol. 127 83 PMID: 3019727
Foldes-Filep et al (1987) Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. Biochem.Biophys.Res.Commun. 148 1412 PMID: 2825685
Maclennan et al (2002) The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog.Neurobiol. 67 235 PMID: 12169298
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Keywords: Ginkgolide B, Ginkgolide B supplier, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, GinkgolideB, BN52021, BN, 52021, (PAF), 1657, Tocris Bioscience
1 Citation for Ginkgolide B
Citations are publications that use Tocris products. Selected citations for Ginkgolide B include:
Huang et al (2015) Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. Nat Neurosci 15 50 PMID: 25956877
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