Ginkgolide B

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Cat.No. 1657 - Ginkgolide B | C20H24O10 | CAS No. 15291-77-7
Description: PAF receptor antagonist
Alternative Names: BN 52021
Chemical Name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
Datasheet
Citations (1)
Literature

Biological Activity

Platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.

Compound Libraries

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Technical Data

M. Wt 424.4
Formula C20H24O10
Storage Desiccate at +4°C
CAS Number 15291-77-7
PubChem ID 10971931
InChI Key SQOJOAFXDQDRGF-OTJOYSMWSA-N
Smiles O=C1[C@@H](C)[C@@]2(O)[C@@]([C@H](O)C34[C@]52O[C@@]6([H])[C@]([C@@H](O)C(O6)=O)3[C@H]([C@](C)(C)C)C[C@H]4O[C@]5=O)([H])O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.44 100
ethanol 10.61 25

Preparing Stock Solutions

The following data is based on the product molecular weight 424.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.36 mL 11.78 mL 23.56 mL
5 mM 0.47 mL 2.36 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.36 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Desquand et al (1986) Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. Eur.J.Pharmacol. 127 83 PMID: 3019727

Foldes-Filep et al (1987) Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. Biochem.Biophys.Res.Commun. 148 1412 PMID: 2825685

Maclennan et al (2002) The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog.Neurobiol. 67 235 PMID: 12169298


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Keywords: Ginkgolide B, supplier, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, GinkgolideB, BN52021, BN, 52021, Platelet-activating, Factor, (PAF), Receptors, Platelet-activating, Factor, (PAF), Receptors, Tocris Bioscience

1 Citation for Ginkgolide B

Citations are publications that use Tocris products. Selected citations for Ginkgolide B include:

Huang et al (2015) Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. Nat Neurosci 15 50 PMID: 25956877


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