Home / Pharmacology / GPCRs / 7-TM Receptors / Platelet-Activating Factor (PAF) Receptors / Platelet-Activating Factor (PAF) Receptor Antagonists / Ginkgolide B

Ginkgolide B

Cat. No. 1657 1 Citation Submit a Review Datasheet / COA / SDS

Discontinued Product

1657 has been discontinued.

View all Platelet-Activating Factor (PAF) Receptors products.
Description: PAF receptor antagonist
Alternative Names: BN 52021
Chemical Name: (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for Ginkgolide B

Ginkgolide B is a platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.

Technical Data for Ginkgolide B

M. Wt 424.4
Formula C20H24O10
Storage Desiccate at +4°C
CAS Number 15291-77-7
PubChem ID 10971931
InChI Key SQOJOAFXDQDRGF-OTJOYSMWSA-N
Smiles O=C1[C@@H](C)[C@@]2(O)[C@@]([C@H](O)C34[C@]52O[C@@]6([H])[C@]([C@@H](O)C(O6)=O)3[C@H]([C@](C)(C)C)C[C@H]4O[C@]5=O)([H])O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Ginkgolide B

References are publications that support the biological activity of the product.

Desquand et al (1986) Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. Eur.J.Pharmacol. 127 83 PMID: 3019727

Foldes-Filep et al (1987) Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. Biochem.Biophys.Res.Commun. 148 1412 PMID: 2825685

Maclennan et al (2002) The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog.Neurobiol. 67 235 PMID: 12169298

View Related Products by Target

View Related Products by Product Action

View all Platelet-Activating Factor (PAF) Receptor Antagonists

Keywords: Ginkgolide B, Ginkgolide B supplier, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, GinkgolideB, BN52021, BN, 52021, (PAF), 1657, Tocris Bioscience

1 Citation for Ginkgolide B

Citations are publications that use Tocris products. Selected citations for Ginkgolide B include:

Huang et al (2015) Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. Nat Neurosci 15 50 PMID: 25956877

Reviews for Ginkgolide B

There are currently no reviews for this product. Be the first to review Ginkgolide B and earn rewards!

Have you used Ginkgolide B?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review