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Broad spectrum glutamate receptor antagonist.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||20.42||100 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 204.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.9 mL||24.49 mL||48.98 mL|
|5 mM||0.98 mL||4.9 mL||9.8 mL|
|10 mM||0.49 mL||2.45 mL||4.9 mL|
|50 mM||0.1 mL||0.49 mL||0.98 mL|
References are publications that support the biological activity of the product.
Aksenov et al (2005) Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classical conditioned eyeblinks and neuronal activity. J.Neurophysiol. 93 44 PMID: 15331619
Jones et al (1984) Structure-activity relations of dipeptide antagonists of excitatory amino acids. Neuroscience 13 573 PMID: 6392929
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Keywords: gammaDGG, gammaDGG supplier, Broad, spectrum, glutamate, receptor, antagonists, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, γDGG, gammaDGG, Non-selective, Glutamate, mGlu, 0112, Tocris Bioscience
3 Citations for γDGG
Citations are publications that use Tocris products. Selected citations for γDGG include:
Young and Neher (2009) Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Neuron 63 482 PMID: 19709630
Chen et al (2013) The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci 33 8336 PMID: 23658173
Grueter et al (2008) In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci 28 9261 PMID: 18784306
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Reviews for γDGG
Average Rating: 5 (Based on 1 Review.)
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Being added to perfusion solution at 0.5 mM concentration, gamma-DGG decreased electrical response amplitudes of pharmacologically isolated glutamate receptors in cerebellar neuron, and increased their paired-pulse ratio.
Literature in this Area
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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.
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