γDGG

Pricing Availability Delivery Time Qty
Cat.No. 0112 - gammaDGG | C7H12N2O5 | CAS No. 6729-55-1
Description: Broad spectrum glutamate receptor antagonist
Chemical Name: γ-D-Glutamylglycine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Broad spectrum glutamate receptor antagonist.

Technical Data

M. Wt 204.18
Formula C7H12N2O5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 6729-55-1
PubChem ID 6604701
InChI Key ACIJGUBIMXQCMF-SCSAIBSYSA-N
Smiles N[C@@]([H])([C@](O)=O)CCC(NCC(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. NaOH and to 100 mM in water with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 204.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.9 mL 24.49 mL 48.98 mL
5 mM 0.98 mL 4.9 mL 9.8 mL
10 mM 0.49 mL 2.45 mL 4.9 mL
50 mM 0.1 mL 0.49 mL 0.98 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Aksenov et al (2005) Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classical conditioned eyeblinks and neuronal activity. J.Neurophysiol. 93 44 PMID: 15331619

Jones et al (1984) Structure-activity relations of dipeptide antagonists of excitatory amino acids. Neuroscience 13 573 PMID: 6392929


If you know of a relevant reference for γDGG, please let us know.

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Keywords: Broad spectrum glutamate receptor antagonists Ionotropic Non-Selective iGluR Receptors mGlur Metabotropic γDGG gammaDGG Non-selective Ionotropic Glutamate

2 Citations for γDGG

Citations are publications that use Tocris products. Selected citations for γDGG include:

Chen et al (2013) The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci 33 8336 PMID: 23658173

Young and Neher (2009) Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Neuron 63 482 PMID: 19709630


Do you know of a great paper that uses γDGG from Tocris? If so please let us know.

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Pathways for γDGG

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