γDGG

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Cat.No. 0112 - gammaDGG | C7H12N2O5 | CAS No. 6729-55-1
Description: Broad spectrum glutamatergic antagonist
Chemical Name: γ-D-Glutamylglycine
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews (1)
Literature

Biological Activity

Broad spectrum glutamate receptor antagonist.

Technical Data

M. Wt 204.18
Formula C7H12N2O5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 6729-55-1
PubChem ID 6604701
InChI Key ACIJGUBIMXQCMF-SCSAIBSYSA-N
Smiles N[C@@]([H])([C@](O)=O)CCC(NCC(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in 1eq. NaOH and to 100 mM in water with gentle warming

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Aksenov et al (2005) Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classical conditioned eyeblinks and neuronal activity. J.Neurophysiol. 93 44 PMID: 15331619

Jones et al (1984) Structure-activity relations of dipeptide antagonists of excitatory amino acids. Neuroscience 13 573 PMID: 6392929


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Keywords: gammaDGG, gammaDGG supplier, Broad, spectrum, glutamate, receptor, antagonists, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, γDGG, gammaDGG, Non-selective, Glutamate, mGlu, 0112, Tocris Bioscience

3 Citations for γDGG

Citations are publications that use Tocris products. Selected citations for γDGG include:

Chen et al (2013) The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse. J Neurosci 33 8336 PMID: 23658173

Grueter et al (2008) In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. J Neurosci 28 9261 PMID: 18784306

Young and Neher (2009) Synaptotagmin has an essential function in synaptic vesicle positioning for synchronous release in addition to its role as a calcium sensor. Neuron 63 482 PMID: 19709630


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Reviews for γDGG

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gamma-DGG impact on whole-cell response of cerebellar neuron.
By Anonymous on 06/07/2019
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: Cerebellum

Being added to perfusion solution at 0.5 mM concentration, gamma-DGG decreased electrical response amplitudes of pharmacologically isolated glutamate receptors in cerebellar neuron, and increased their paired-pulse ratio.

PMID: 23242311
review image

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