You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Schiffhauer et al (2013) Dual activation of CFTR and CLCN2 by lubipro. in murine nasal epithelia. Am.J.Physiol.Lung Cell Mol.Physiol. 304 L324 PMID: 23316067
Thompson et al (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J.Biol.Chem. 284 26051 PMID: 19574231
If you know of a relevant reference for GaTx2, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: GaTx2, GaTx2 supplier, high, affinity, ClC-2, blockers, chloride, channels, selective, slow, gating, venoms, Leiuropeptide, II, Other, Chloride, Channels, 4911, Tocris Bioscience
1 Citation for GaTx2
Citations are publications that use Tocris products. Selected citations for GaTx2 include:
Nighot et al (2017) Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin. Exp Cell Res 352 113 PMID: 28161538
Do you know of a great paper that uses GaTx2 from Tocris? Please let us know.
Reviews for GaTx2
There are currently no reviews for this product. Be the first to review GaTx2 and earn rewards!
Have you used GaTx2?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]New
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells