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Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.
(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Schiffhauer et al (2013) Dual activation of CFTR and CLCN2 by lubipro. in murine nasal epithelia. Am.J.Physiol.Lung Cell Mol.Physiol. 304 L324 PMID: 23316067
Thompson et al (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J.Biol.Chem. 284 26051 PMID: 19574231
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Keywords: GaTx2, GaTx2 supplier, high, affinity, ClC-2, blockers, chloride, channels, selective, slow, gating, venoms, Leiuropeptide, II, Other, Chloride, Channels, 4911, Tocris Bioscience
1 Citation for GaTx2
Citations are publications that use Tocris products. Selected citations for GaTx2 include:
Nighot et al (2017) Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin. Exp Cell Res 352 113 PMID: 28161538
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