GaTx2

Pricing Availability Delivery Time Qty
Cat.No. 4911 - GaTx2 | Val-Ser-Cys-Glu-Asp-Cys-Pro-Asp-His-Cys-Ser-Thr-Glu-Lys-Ala-Arg-Ala-Lys-Cys-Asp-Asn-Asp-Lys-Cys-Val-Cys-Glu-Pro-Ile | CAS No. 194665-85-5
Description: High affinity, selective ClC-2 blocker; inhibits slow-gating
Alternative Names: Leiuropeptide II
Datasheet
Citations
Reviews
Literature

Biological Activity

Very high affinity ClC-2 blocker (apparent KD ~ 50 pM). Slows ClC-2 activation and inhibits slow-gating but does not inhibit open ClC-2 channels. Selective for ClC-2 over other ClC family members (ClC-0, ClC-1, ClC-3 and ClC-4), CFTR, GABAC, CaCC and KV1.2.

Technical Data

M. Wt 3192.54
Formula C125H199N39O47S6
Sequence VSCEDCPDHCSTQKARAKCDNDKCVCEPI

(Modifications: Disulfide bridge: 3-19, 6-24, 10-26)

Storage Store at -20°C
CAS Number 194665-85-5
PubChem ID 90488986
InChI Key NDCNPIYRYDSDEM-TZZHORBYSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(O)=O)[C@@H](C)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3192.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.31 mL 1.57 mL 3.13 mL
5 mM 0.06 mL 0.31 mL 0.63 mL
10 mM 0.03 mL 0.16 mL 0.31 mL
50 mM 0.01 mL 0.03 mL 0.06 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Schiffhauer et al (2013) Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia. Am.J.Physiol.Lung Cell Mol.Physiol. 304 L324 PMID: 23316067

Thompson et al (2009) Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J.Biol.Chem. 284 26051 PMID: 19574231


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Keywords: GaTx2, supplier, high, affinity, ClC-2, blockers, chloride, channels, selective, slow, gating, venoms, Leiuropeptide, II, Other, Chloride, Channels, Other, Chloride, Channels, Tocris Bioscience

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