Garcinol

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Cat.No. 4827 - Garcinol | C38H50O6 | CAS No. 78824-30-3
Description: PCAF/p300 inhibitor; anticancer
Chemical Name: (1R,5R,7R)-3-(3,4-Dihydroxybenzyol)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]bicyclo[3.3.1]non-3-ene-2,9-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of PCAF and p300 histone acetyltransferase (HAT) activity (IC50 values are 5 and 7 μM, respectively). Promotes expansion of human HSCs ex vivo. Causes reversal of EMT and inhibits β-catenin in breast cancer cell lines MDA-MB-231 and BT-549.

Technical Data

M. Wt 602.8
Formula C38H50O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 78824-30-3
PubChem ID 22245705
InChI Key KCODNOOPOPTZMO-UHFFFAOYSA-N
Smiles O=C1C(C(C2=CC(O)=C(O)C=C2)=O)=C(O)[C@](C[C@H](C/C=C(C)/C)C(C)=C)([C@@]3=O)C[C@@H](C/C=C(C)/C)C(C)(C)[C@]31C/C=C(C)\C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 60.28 100
ethanol 60.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 602.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.66 mL 8.29 mL 16.59 mL
5 mM 0.33 mL 1.66 mL 3.32 mL
10 mM 0.17 mL 0.83 mL 1.66 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Ahmad et al (2012) Garcinol regulates EMT and Wnt signaling pathways in vitro and in vivo, leading to anticancer activity against breast cancer cells. Mol.Cancer.Ther. 11 2193 PMID: 22821148

Balasubramanyam et al (2004) Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. J.Biol.Chem. 279 33716 PMID: 15155757

Nishino et al (2011) Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One 6 e24298 PMID: 21931675


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View all Histone Acetyltransferase Inhibitors

Keywords: Garcinol, supplier, inhibitors, inhibits, histone, acetyltransferase, HAT, PCAF, p300, HSCs, EMT, MET, β-catenin, breast, cancer, hematopoietic, stem, cells, epithelial, to, mesenchymal, transition, Histone, Acetyltransferases, Stem, Cell, Proliferation, Histone, Acetyltransferases, Tocris Bioscience

Citations for Garcinol

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Literature in this Area

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Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

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