Galnon

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Cat.No. 2085 - Galnon | Fmoc-β-cyclohexyl-Ala-Lys-(4-methyl-2-oxo-2H-1-benzopyran) | CAS No. 475115-35-6
Description: Non-selective galanin receptor agonist
Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
Datasheet
Citations
Literature

Biological Activity

Novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.

Technical Data

M. Wt 678.83
Formula C40H46N4O6
Sequence AK

(Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran)

Storage Desiccate at -20°C
CAS Number 475115-35-6
PubChem ID 5311268
InChI Key IKNOZZKXIDSTRN-PXLJZGITSA-N
Smiles CC1=CC(=O)OC2=C1C=CC(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1CCCCC1)NC(=O)OCC1C3=CC=CC=C3C3=C1C=CC=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 67.88 mg/ml in DMSO and to 16.97 mg/ml in ethanol with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 678.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.47 mL 7.37 mL 14.73 mL
5 mM 0.29 mL 1.47 mL 2.95 mL
10 mM 0.15 mL 0.74 mL 1.47 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Abramov et al (2004) Regulation of feeding by galnon. Neuropeptides 38 55 PMID: 15003717

Saar et al (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist Proc.Natl.Acad.Sci.USA 99 7136 PMID: 12011470

Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci. 102 874 PMID: 15647369

Quynh et al (2005) Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem.Biophys.Res.Comm. 328 213 PMID: 15670772


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Keywords: Galnon, supplier, Selective, non-peptide, GAL1, GalR1, agonists, Receptors, Galanin, Galanin, Receptors, Tocris Bioscience

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