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Novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.
(Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 67.88 mg/ml in DMSO and to 16.97 mg/ml in ethanol with gentle warming|
References are publications that support the biological activity of the product.
Abramov et al (2004) Regulation of feeding by galnon. Neuropeptides 38 55 PMID: 15003717
Saar et al (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist Proc.Natl.Acad.Sci.USA 99 7136 PMID: 12011470
Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci. 102 874 PMID: 15647369
Quynh et al (2005) Effects of galnon, a non-peptide galanin-receptor agonist, on Ins release from rat pancreatic islets. Biochem.Biophys.Res.Comm. 328 213 PMID: 15670772
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Keywords: Galnon, Galnon supplier, Selective, non-peptide, GAL1, GalR1, agonists, Receptors, Galanin, 2085, Tocris Bioscience
1 Citation for Galnon
Citations are publications that use Tocris products. Selected citations for Galnon include:
Einstein et al (2013) Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and mor. conditioned place preference require both galanin receptor 1 and galanin receptor 2. Eur J Neurosci 37 1541 PMID: 23387435
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.