Galnon

Pricing Availability   Qty
Cat.No. 2085 - Galnon | Fmoc-β-cyclohexyl-Ala-Lys-(4-methyl-2-oxo-2H-1-benzopyran) | CAS No. 475115-35-6
Description: Non-selective galanin receptor agonist
Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.

Technical Data

M. Wt 678.83
Formula C40H46N4O6
Sequence AK

(Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran)

Storage Desiccate at -20°C
CAS Number 475115-35-6
PubChem ID 5311268
InChI Key IKNOZZKXIDSTRN-PXLJZGITSA-N
Smiles CC1=CC(=O)OC2=C1C=CC(NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC1CCCCC1)NC(=O)OCC1C3=CC=CC=C3C3=C1C=CC=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 67.88 mg/ml in DMSO and to 16.97 mg/ml in ethanol with gentle warming

References

References are publications that support the biological activity of the product.

Abramov et al (2004) Regulation of feeding by galnon. Neuropeptides 38 55 PMID: 15003717

Saar et al (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist Proc.Natl.Acad.Sci.USA 99 7136 PMID: 12011470

Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci. 102 874 PMID: 15647369

Quynh et al (2005) Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem.Biophys.Res.Comm. 328 213 PMID: 15670772


If you know of a relevant reference for Galnon, please let us know.

View Related Products by Product Action

View all Galanin Receptor Agonists

Keywords: Galnon, Galnon supplier, Selective, non-peptide, GAL1, GalR1, agonists, Receptors, Galanin, 2085, Tocris Bioscience

1 Citation for Galnon

Citations are publications that use Tocris products. Selected citations for Galnon include:

Einstein et al (2013) Galanin-induced decreases in nucleus accumbens/striatum excitatory postsynaptic potentials and morphine conditioned place preference require both galanin receptor 1 and galanin receptor 2. Eur J Neurosci 37 1541 PMID: 23387435


Do you know of a great paper that uses Galnon from Tocris? Please let us know.

Reviews for Galnon

There are currently no reviews for this product. Be the first to review Galnon and earn rewards!

Have you used Galnon?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing
Peptides Involved in Appetite Modulation

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.