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G6PDi 1

Cat. No. 7561 Submit a Review Datasheet / COA / SDS
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Description: Potent, reversible glucose-6-phosphate dehydrogenase (G6PD) inhibitor
Chemical Name: 4-((5-Oxo-6,7,8,9-tetrahydro-5H-cyclohepta[d]pyrimidin-2-yl)amino)thiophene-2-carbonitrile
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for G6PDi 1

G6PDi 1 is a potent, reversible, nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD) (IC50 = 70 nM. The compound dose-dependently and reversibly decreases 6-phosphogluconolactone (6-PG) levels in HCT116 and HepG2 cell lines in vitro. In activated T cells, G6PDi-1 inhibits flux through the pentose phosphate pathway and decreases NADPH generation. It also inhibits production of cytokines by activated T cells and oxidative burst in neutrophils.

Licensing Information

Sold under license from Princeton University

Technical Data for G6PDi 1

M. Wt 284.34
Formula C14H12N4OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2457232-14-1
PubChem ID 145998284
InChI Key USWCHVCZOGGQQA-UHFFFAOYSA-N
Smiles O=C1CCCCC2=NC(NC3=CSC(C#N)=C3)=NC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for G6PDi 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.43 100

Preparing Stock Solutions for G6PDi 1

The following data is based on the product molecular weight 284.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.52 mL 17.58 mL 35.17 mL
5 mM 0.7 mL 3.52 mL 7.03 mL
10 mM 0.35 mL 1.76 mL 3.52 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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References for G6PDi 1

References are publications that support the biological activity of the product.

Ghergurovich et al (2020) A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway. Nat.Chem.Biol. 16 731 PMID: 32393898

If you know of a relevant reference for G6PDi 1, please let us know.

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Citations for G6PDi 1

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