Antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC50 = 112 nM). Structural analog of G-1 (Cat. No. 3577).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 412.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.43 mL||12.13 mL||24.25 mL|
|5 mM||0.49 mL||2.43 mL||4.85 mL|
|10 mM||0.24 mL||1.21 mL||2.43 mL|
|50 mM||0.05 mL||0.24 mL||0.49 mL|
References are publications that support the biological activity of the product.
Prossnitz and Barton (2011) The G-protein-coupled estrogen receptor GPER in health and disease. Nat.Rev.Endocrinol. 7 715 PMID: 21844907
Dennis et al (2011) Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J.Steroid Biochem.Mol.Biol. 127 358 PMID: 21782022
If you know of a relevant reference for G-36, please let us know.
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Keywords: G-36, G-36 supplier, G36, G-protein-coupled, estrogen, receptors, GPER, GPR30, antagonists, selective, Estrogen, (GPER), Receptors, 4759, Tocris Bioscience
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