G 28UCM

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Cat.No. 5446 - G 28UCM | C24H16O10 | CAS No. 1094451-90-7
Description: FASN inhibitor
Chemical Name: 3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

FASN inhibitor. Inhibits breast cancer cell proliferation in vitro (IC50 values are 21 - 79 μM), including cell lines resistant to anti-HER2 therapies. Blocks HER2 signaling and induces apoptosis. Inhibits growth of breast cancer xenografts in mice without causing anorexia.

Technical Data

M. Wt 464.38
Formula C24H16O10
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1094451-90-7
PubChem ID 24896615
InChI Key KJCWIWDPTNVWRX-UHFFFAOYSA-N
Smiles O=C(C3=CC(O)=C(O)C(O)=C3)OC2=CC(OC(C4=CC(O)=C(O)C(O)=C4)=O)=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.44 100
ethanol 46.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 464.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.77 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Puig et al (2011) A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 13 R131 PMID: 22177475

Puig et al (2009) Novel inhibitors of fatty acid synthase with anticancer activity. Clin.Cancer Res. 15 7608 PMID: 20008854


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Citations for G 28UCM

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Literature in this Area

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis