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G 28UCM

Cat. No. 5446 1 Citation Submit a Review Datasheet / COA / SDS
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Cat.No. 5446 - G 28UCM | C24H16O10 | CAS No. 1094451-90-7
Description: FASN inhibitor
Chemical Name: 3-(3,4,5-Trihydroxybenzoyloxy)naphthalen-1-yl 3,4,5-trihydroxybenzoate
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for G 28UCM

G 28UCM is a FASN inhibitor. Inhibits breast cancer cell proliferation in vitro (IC50 values are 21 - 79 μM), including cell lines resistant to anti-HER2 therapies. Blocks HER2 signaling and induces apoptosis. Inhibits growth of breast cancer xenografts in mice without causing anorexia.

Technical Data for G 28UCM

M. Wt 464.38
Formula C24H16O10
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1094451-90-7
PubChem ID 24896615
InChI Key KJCWIWDPTNVWRX-UHFFFAOYSA-N
Smiles O=C(C3=CC(O)=C(O)C(O)=C3)OC2=CC(OC(C4=CC(O)=C(O)C(O)=C4)=O)=CC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for G 28UCM

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.44 100
ethanol 46.44 100

Preparing Stock Solutions for G 28UCM

The following data is based on the product molecular weight 464.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.77 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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References for G 28UCM

References are publications that support the biological activity of the product.

Puig et al (2011) A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines. Breast Cancer Res. 13 R131 PMID: 22177475

Puig et al (2009) Novel inhibitors of fatty acid synthase with anticancer activity. Clin.Cancer Res. 15 7608 PMID: 20008854

If you know of a relevant reference for G 28UCM, please let us know.

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Keywords: G 28UCM, G 28UCM supplier, G28UCM, fatty, acid, synthase, inhibitors, inhibits, FASN, breast, cancer, Fatty, Acid, Synthase, 5446, Tocris Bioscience

1 Citation for G 28UCM

Citations are publications that use Tocris products. Selected citations for G 28UCM include:

Chu et al (2021) Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat.Metab. 3 1466 PMID: 34580494

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Literature in this Area

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