Furanone C-30

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Description: Quorum sensing inhibitor; antibacterial
Chemical Name: (5Z)-4-Bromo-5-(bromomethylene)-2(5H)-furanone
Purity: ≥98%

Biological Activity for Furanone C-30

Furanone C-30 is a synthetic furanone bacterial quorum sensing inhibitor. Inhibits virulence factor expression in Pseudomonas aeruginosa and increases bacterial susceptibility to antibiotics in vitro. Also inhibits bacterial quorum sensing in vivo and promotes bacterial clearance in a mouse pulmonary infection model.

Technical Data for Furanone C-30

M. Wt 253.88
Formula C5H2Br2O2
Storage Store at -20°C
Purity ≥98%
CAS Number 247167-54-0
PubChem ID 67228456
Smiles Br/C=C1OC(C=C\1Br)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Furanone C-30

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.39 100

Preparing Stock Solutions for Furanone C-30

The following data is based on the product molecular weight 253.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.94 mL 19.69 mL 39.39 mL
5 mM 0.79 mL 3.94 mL 7.88 mL
10 mM 0.39 mL 1.97 mL 3.94 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets for Furanone C-30

References for Furanone C-30

References are publications that support the biological activity of the product.

Hentzer et al (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J. 22 3803 PMID: 12881415

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Keywords: Furanone C-30, Furanone C-30 supplier, quorum, sensing, sensors, Gram-negative, signaling, signalling, inhibits, inhibitors, antibacterial, Antibiotics, 6546, Tocris Bioscience

Citations for Furanone C-30

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