Discontinued ProductUnfortunately FTI 276 (Cat. No. 2406) has been withdrawn from sale for commercial reasons.
Ras CAAX peptidomimetic, a selective inhibitor of farnesyltransferase (FTase) that displays > 100-fold selectivity over geranylgeranyltransferase I (GGTase I) (IC50 values are 0.5 and 50 nM respectively). Blocks growth of human lung carcinoma expressing oncogenic K-Ras in nude mice.
|Storage||Store at -80°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 547.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.83 mL||9.13 mL||18.26 mL|
|5 mM||0.37 mL||1.83 mL||3.65 mL|
|10 mM||0.18 mL||0.91 mL||1.83 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References are publications that support the products' biological activity.
Sun et al (1995) Ras CAAX peptidomimetic FTI 276 selectively blocks tumour growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res. 55 4243 PMID: 7671229
Lerner et al (1995) Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling inducing cytoplasic accumulation of inactive Ras-Raf complexes. J.Biol.Chem. 270 26802 PMID: 7592920
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Keywords: FTI 276, supplier, Ras, CAAX, peptidomimetic, inhibitors, inhibits, farnesyltransferase, FTase, geranylgeranyltransferase, GGTase, carcinoma, K-Ras, tumour, tumor, FTI276, Protein, Prenyltransferases, Post-translational, Modifications, Protein, Prenyltransferases, Tocris Bioscience
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