FTI 276

Discontinued Product

Unfortunately FTI 276 (Cat. No. 2406) has been withdrawn from sale for commercial reasons.
Cat.No. 2406 - FTI 276 | C21H27N3O3S2.C2HF3O2 | CAS No. 1217471-51-6
Description: Farnesyltransferase (FTase) inhibitor; antitumor
Chemical Name: N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine trifluoroacetate salt
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Ras CAAX peptidomimetic, a selective inhibitor of farnesyltransferase (FTase) that displays > 100-fold selectivity over geranylgeranyltransferase I (GGTase I) (IC50 values are 0.5 and 50 nM respectively). Blocks growth of human lung carcinoma expressing oncogenic K-Ras in nude mice.

Technical Data

M. Wt 547.61
Formula C21H27N3O3S2.C2HF3O2
Storage Store at -80°C
Purity ≥95% (HPLC)
CAS Number 1217471-51-6
PubChem ID 395753
Smiles SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@](O)=O)CCSC)=O)C(C2=CC=CC=C2)=C1.FC(F)(C(O)=O)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 547.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.83 mL 9.13 mL 18.26 mL
5 mM 0.37 mL 1.83 mL 3.65 mL
10 mM 0.18 mL 0.91 mL 1.83 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sun et al (1995) Ras CAAX peptidomimetic FTI 276 selectively blocks tumour growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion. Cancer Res. 55 4243 PMID: 7671229

Lerner et al (1995) Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling inducing cytoplasic accumulation of inactive Ras-Raf complexes. J.Biol.Chem. 270 26802 PMID: 7592920

Lerner et al (1995) Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J.Biol.Chem. 10 26770 PMID:

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Keywords: Ras CAAX peptidomimetic inhibitors inhibits farnesyltransferase FTase geranylgeranyltransferase GGTase carcinoma K-Ras tumour tumor FTI276 Protein Prenyltransferases

Citations for FTI 276

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for FTI 276

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