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Potent and selective GPR52 agonist (EC50 = 75 nM, Emax = 122%). Selective for GPR52 over a panel of 98 targets including D1, D2, AMPA and NMDA. Suppresses methamphetamine-induced hyperlocomotion in mice. Inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. Orally bioavailable and brain penetrant.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 392.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.55 mL||12.74 mL||25.49 mL|
|5 mM||0.51 mL||2.55 mL||5.1 mL|
|10 mM||0.25 mL||1.27 mL||2.55 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References are publications that support the biological activity of the product.
Tokumaru et al (2017) Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg.Med.Chem. 25 3098 PMID: 28433511
Nishiyama et al (2017) FTBMT, a novel and selective GPR52 agonist, demonstrates antipsychotic-like and procognitive effects in rodents, revealing a potential therapeutic agent for schizophrenia. J.Pharmacol.Exp.Ther. 363 253 PMID: 28851764
If you know of a relevant reference for FTBMT, please let us know.
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Keywords: FTBMT, FTBMT supplier, GPR52, agonist, agonism, potent, selective, Schizophrenia, psychosis, orally, bioavailable, and, BBB, permeable, Orphan, 7-TM, Receptors, 6784, Tocris Bioscience
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Literature in this Area
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