You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for FTBMT
FTBMT (also known as TP 024) is a potent and selective GPR52 agonist (EC50 = 75 nM, Emax = 122%), which is selective for GPR52 over a panel of 98 targets including D1, D2, AMPA and NMDA. FTBMT suppresses methamphetamine-induced hyperlocomotion in mice, and inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. This compound is orally bioavailable and brain penetrant.
External Portal Information for FTBMT
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of FTBMT (TP 024) is reviewed on chemicalprobes.org and the SGC website.
Compound Libraries for FTBMT
Technical Data for FTBMT
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FTBMT
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FTBMT
The following data is based on the product molecular weight 392.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.55 mL||12.74 mL||25.49 mL|
|5 mM||0.51 mL||2.55 mL||5.1 mL|
|10 mM||0.25 mL||1.27 mL||2.55 mL|
|50 mM||0.05 mL||0.25 mL||0.51 mL|
References for FTBMT
References are publications that support the biological activity of the product.
Tokumaru et al (2017) Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg.Med.Chem. 25 3098 PMID: 28433511
Nishiyama et al (2017) FTBMT, a novel and selective GPR52 agonist, demonstrates antipsychotic-like and procognitive effects in rodents, revealing a potential therapeutic agent for schizophrenia. J.Pharmacol.Exp.Ther. 363 253 PMID: 28851764
If you know of a relevant reference for FTBMT, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: FTBMT, FTBMT supplier, GPR52, agonist, agonism, potent, selective, Schizophrenia, psychosis, orally, bioavailable, and, BBB, permeable, TP-024, Orphan, 7-TM, Receptors, 6784, Tocris Bioscience
Citations for FTBMT
Citations are publications that use Tocris products.
Currently there are no citations for FTBMT. Do you know of a great paper that uses FTBMT from Tocris? Please let us know.
Reviews for FTBMT
There are currently no reviews for this product. Be the first to review FTBMT and earn rewards!
Have you used FTBMT?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.