Pricing Availability   Qty
Description: Potent and selective GPR52 agonist; orally bioavailable and BBB permeable
Alternative Names: TP-024
Chemical Name: 4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide
Purity: ≥98% (HPLC)

Biological Activity for FTBMT

FTBMT (also known as TP 024) is a potent and selective GPR52 agonist (EC50 = 75 nM, Emax = 122%), which is selective for GPR52 over a panel of 98 targets including D1, D2, AMPA and NMDA. FTBMT suppresses methamphetamine-induced hyperlocomotion in mice, and inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. This compound is orally bioavailable and brain penetrant.

External Portal Information for FTBMT

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of FTBMT (TP 024) is reviewed on chemicalprobes.org and the SGC website.

Compound Libraries for FTBMT

FTBMT is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for FTBMT

M. Wt 392.35
Formula C19H16F4N4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1358575-02-6
PubChem ID 56649300
Smiles CC1=NC(CC2=CC(C(F)(F)F)=CC(F)=C2)=NN1C3=CC(C)=C(C(N)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FTBMT

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.23 100
ethanol 19.62 50

Preparing Stock Solutions for FTBMT

The following data is based on the product molecular weight 392.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets for FTBMT

Certificate of Analysis / Product Datasheet
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References for FTBMT

References are publications that support the biological activity of the product.

Tokumaru et al (2017) Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg.Med.Chem. 25 3098 PMID: 28433511

Nishiyama et al (2017) FTBMT, a novel and selective GPR52 agonist, demonstrates antipsychotic-like and procognitive effects in rodents, revealing a potential therapeutic agent for schizophrenia. J.Pharmacol.Exp.Ther. 363 253 PMID: 28851764

If you know of a relevant reference for FTBMT, please let us know.

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Keywords: FTBMT, FTBMT supplier, GPR52, agonist, agonism, potent, selective, Schizophrenia, psychosis, orally, bioavailable, and, BBB, permeable, TP-024, Orphan, 7-TM, Receptors, 6784, Tocris Bioscience

Citations for FTBMT

Citations are publications that use Tocris products.

Currently there are no citations for FTBMT. Do you know of a great paper that uses FTBMT from Tocris? Please let us know.

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