FTBMT

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Cat.No. 6784 - FTBMT | C19H16F4N4O | CAS No. 1358575-02-6
Description: Potent and selective GPR52 agonist; orally bioavailable and BBB permeable
Chemical Name: 4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective GPR52 agonist (EC50 = 75 nM, Emax = 122%). Selective for GPR52 over a panel of 98 targets including D1, D2, AMPA and NMDA. Suppresses methamphetamine-induced hyperlocomotion in mice. Inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. Orally bioavailable and brain penetrant.

Technical Data

M. Wt 392.35
Formula C19H16F4N4O
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1358575-02-6
PubChem ID 56649300
InChI Key TYXSIXOYTBHZFA-UHFFFAOYSA-N
Smiles CC1=NC(CC2=CC(C(F)(F)F)=CC(F)=C2)=NN1C3=CC(C)=C(C(N)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.23 100
ethanol 19.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 392.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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References

References are publications that support the biological activity of the product.

Tokumaru et al (2017) Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg.Med.Chem. 25 3098 PMID: 28433511

Nishiyama et al (2017) FTBMT, a novel and selective GPR52 agonist, demonstrates antipsychotic-like and procognitive effects in rodents, revealing a potential therapeutic agent for schizophrenia. J.Pharmacol.Exp.Ther. 363 253 PMID: 28851764


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