FSL 1

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Cat.No. 6011 - FSL 1 | Pam2-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe | CAS No. 322455-70-9
Description: TLR2/6 agonist (also a putative TLR10 ligand)
Datasheet
Citations
Reviews (1)
Literature (2)
Pathways (1)

Biological Activity

TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.

Technical Data

M. Wt 1666.16
Formula C84H140N14O18S
Sequence CGDPKHPKSF

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys)

Storage Store at -20°C
CAS Number 322455-70-9
PubChem ID 87858248
InChI Key VJJLLNHELGKSNA-YWKNMTRCSA-N
Smiles CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Okusawa et al (2004) Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect.Immun. 72 1657 PMID: 14977973

Mauldin et al (2015) TLR2/6 agonists and IF.-gamma induce human melanoma cells to produce CXCL10. Int.J.Cancer 137 1386 PMID: 25765738

Le et al (2016) Stable toll-like receptor 10 knockdown in THP-1 cells reduces TLR-ligand-induced proinflammatory cytokine expression. Int.J.Mol.Sci. 17 E859 PMID: 27258267


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Keywords: FSL 1, FSL 1 supplier, FSL1, TLR2/6, agonists, agonism, putative, TLR10, ligands, Toll-like, receptors, induces, inducers, TNF-α, TNF-alpha, TNF-a, tumor, tumour, necrosis, factor, NFκB, NFKB, HGF, Receptors, 6011, Tocris Bioscience

Citations for FSL 1

Citations are publications that use Tocris products.

Currently there are no citations for FSL 1. Do you know of a great paper that uses FSL 1 from Tocris? Please let us know.

Reviews for FSL 1

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FSL-1 works well for inducing TLR2 signaling.
By Xiaogang Wang on 09/15/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: THP-1

We used this molecule to serve as a control to induce TLR2 signaling. The differentiated THP-1 macrophages were treated with FSL-1 for staphylococcus aureus lipoproteins for 4 h and the TNFa in culture supernatants was measured by ELISA.

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Literature in this Area

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Pathways for FSL 1

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.