FSL 1

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Cat.No. 6011 - FSL 1 | Pam2-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe | CAS No. 322455-70-9
Description: TLR2/6 agonist (also a putative TLR10 ligand)
Datasheet
Citations
Literature
Pathways

Biological Activity

TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.

Technical Data

M. Wt 1666.16
Formula C84H140N14O18S
Sequence CGDPKHPKSF

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys)

Storage Store at -20°C
CAS Number 322455-70-9
PubChem ID 87858248
InChI Key VJJLLNHELGKSNA-YWKNMTRCSA-N
Smiles CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1666.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.6 mL 3 mL 6 mL
5 mM 0.12 mL 0.6 mL 1.2 mL
10 mM 0.06 mL 0.3 mL 0.6 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Okusawa et al (2004) Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect.Immun. 72 1657 PMID: 14977973

Mauldin et al (2015) TLR2/6 agonists and interferon-gamma induce human melanoma cells to produce CXCL10. Int.J.Cancer 137 1386 PMID: 25765738

Le et al (2016) Stable toll-like receptor 10 knockdown in THP-1 cells reduces TLR-ligand-induced proinflammatory cytokine expression. Int.J.Mol.Sci. 17 E859 PMID: 27258267


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Citations for FSL 1

Citations are publications that use Tocris products.

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for FSL 1

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.

Protocols

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