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Cat.No. 6011 - FSL 1 | Pam2-Cys-Gly-Asp-Pro-Lys-His-Pro-Lys-Ser-Phe | CAS No. 322455-70-9
Description: TLR2/6 agonist (also a putative TLR10 ligand)
Literature (2)
Pathways (1)

Biological Activity

TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.

Technical Data

M. Wt 1666.16
Formula C84H140N14O18S

(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys)

Storage Store at -20°C
CAS Number 322455-70-9
PubChem ID 87858248

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Okusawa et al (2004) Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect.Immun. 72 1657 PMID: 14977973

Mauldin et al (2015) TLR2/6 agonists and IF.-gamma induce human melanoma cells to produce CXCL10. Int.J.Cancer 137 1386 PMID: 25765738

Le et al (2016) Stable toll-like receptor 10 knockdown in THP-1 cells reduces TLR-ligand-induced proinflammatory cytokine expression. Int.J.Mol.Sci. 17 E859 PMID: 27258267

If you know of a relevant reference for FSL 1, please let us know.

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Citations for FSL 1

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for FSL 1

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.