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Biological Activity for FSL 1
FSL 1 is a TLR2/6 agonist (also a putative TLR10 ligand). Activates NF-κB. Induces pro-inflammatory cytokines including IL-8, IL-1β, CCL20 and TNF-α in vitro. Synergizes with IFNγ to induce CXCL10 release from melanoma cells.
Technical Data for FSL 1
(Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for FSL 1
References are publications that support the biological activity of the product.
Okusawa et al (2004) Relationship between structures and biological activities of mycoplasmal diacylated lipopeptides and their recognition by toll-like receptors 2 and 6. Infect.Immun. 72 1657 PMID: 14977973
Mauldin et al (2015) TLR2/6 agonists and IF.-gamma induce human melanoma cells to produce CXCL10. Int.J.Cancer 137 1386 PMID: 25765738
Le et al (2016) Stable toll-like receptor 10 knockdown in THP-1 cells reduces TLR-ligand-induced proinflammatory cytokine expression. Int.J.Mol.Sci. 17 E859 PMID: 27258267
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Keywords: FSL 1, FSL 1 supplier, FSL1, TLR2/6, agonists, agonism, putative, TLR10, ligands, Toll-like, receptors, induces, inducers, TNF-α, TNF-alpha, TNF-a, tumor, tumour, necrosis, factor, NFκB, NFKB, HGF, Receptors, 6011, Tocris Bioscience
Citations for FSL 1
Citations are publications that use Tocris products.
Currently there are no citations for FSL 1.
Reviews for FSL 1
Average Rating: 5 (Based on 1 Review.)
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We used this molecule to serve as a control to induce TLR2 signaling. The differentiated THP-1 macrophages were treated with FSL-1 for staphylococcus aureus lipoproteins for 4 h and the TNFa in culture supernatants was measured by ELISA.
Literature in this Area
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