Foxy 5

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Cat.No. 5461 - Foxy 5 | N-Formyl-Met-Asp-Gly-Cys-Glu-Leu | CAS No. 881188-51-8
Description: Wnt5a peptide mimetic
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Wnt5a peptide mimetic. Impairs migration and invasion of 4T1 breast cancer cells in vitro. Also inhibits metastasis of inoculated 4T1 cells in mice.

Technical Data

M. Wt 694.77
Formula C26H42N6O12S2
Sequence MDGCEL

(Modifications: Met-1 = N-Formyl)

Storage Store at -20°C
CAS Number 881188-51-8
PubChem ID 44628955
InChI Key WFZPJYYCTSHDJI-ATIWLJMLSA-N
Smiles [H]N([C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)[C@H](CCSC)NC=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solubility Soluble to 1 mg/ml in PBS (pH 7.4)

Preparing Stock Solutions

The following data is based on the product molecular weight 694.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.44 mL 7.2 mL 14.39 mL
5 mM 0.29 mL 1.44 mL 2.88 mL
10 mM 0.14 mL 0.72 mL 1.44 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Säfholm et al (2008) The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin.Cancer Res. 14 6556 PMID: 18927296

Säfholm et al (2006) A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J.Biol.Chem. 281 2740 PMID: 16330545


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Keywords: Foxy 5, Foxy 5 supplier, Foxy5, wnt5a, peptide, mimetic, Other, Wnt, Signaling, 5461, Tocris Bioscience

Citations for Foxy 5

Citations are publications that use Tocris products.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Foxy 5

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.