Foxy 5

Pricing Availability   Qty
Description: Wnt5a peptide mimetic
Purity: ≥95% (HPLC)
Citations (1)
Pathways (1)

Biological Activity for Foxy 5

Foxy 5 is a Wnt5a peptide mimetic. Impairs migration and invasion of 4T1 breast cancer cells in vitro. Also inhibits metastasis of inoculated 4T1 cells in mice.

Technical Data for Foxy 5

M. Wt 694.77
Formula C26H42N6O12S2
Sequence MDGCEL

(Modifications: Met-1 = N-Formyl)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 881188-51-8
PubChem ID 44628955
Smiles [H]N([C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)[C@H](CCSC)NC=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Foxy 5

Solubility Soluble to 1 mg/ml in PBS (pH 7.4)

Product Datasheets for Foxy 5

Certificate of Analysis / Product Datasheet
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References for Foxy 5

References are publications that support the biological activity of the product.

Säfholm et al (2008) The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin.Cancer Res. 14 6556 PMID: 18927296

Säfholm et al (2006) A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J.Biol.Chem. 281 2740 PMID: 16330545

If you know of a relevant reference for Foxy 5, please let us know.

Keywords: Foxy 5, Foxy 5 supplier, Foxy5, wnt5a, peptide, mimetic, Other, Wnt, Signaling, 5461, Tocris Bioscience

1 Citation for Foxy 5

Citations are publications that use Tocris products. Selected citations for Foxy 5 include:

Ling et al (2021) Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids. Cell Stem Cell 28 1090-1104.e6 PMID: 33915081

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Pathways for Foxy 5

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.