Wnt5a peptide mimetic. Impairs migration and invasion of 4T1 breast cancer cells in vitro. Also inhibits metastasis of inoculated 4T1 cells in mice.
(Modifications: Met-1 = N-Formyl)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in PBS (pH 7.4)|
Preparing Stock Solutions
The following data is based on the product molecular weight 694.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.44 mL||7.2 mL||14.39 mL|
|5 mM||0.29 mL||1.44 mL||2.88 mL|
|10 mM||0.14 mL||0.72 mL||1.44 mL|
|50 mM||0.03 mL||0.14 mL||0.29 mL|
References are publications that support the products' biological activity.
Säfholm et al (2008) The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin.Cancer Res. 14 6556 PMID: 18927296
Säfholm et al (2006) A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J.Biol.Chem. 281 2740 PMID: 16330545
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Keywords: Foxy 5, supplier, Foxy5, wnt5a, peptide, mimetic, Other, Wnt, Signaling, Other, Wnt, Signaling, Tocris Bioscience
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