Foxy 5

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Cat.No. 5461 - Foxy 5 | N-Formyl-Met-Asp-Gly-Cys-Glu-Leu | CAS No. 881188-51-8
Description: Wnt5a peptide mimetic
Datasheet
Citations
Literature
Pathways

Biological Activity

Wnt5a peptide mimetic. Impairs migration and invasion of 4T1 breast cancer cells in vitro. Also inhibits metastasis of inoculated 4T1 cells in mice.

Technical Data

M. Wt 694.77
Formula C26H42N6O12S2
Sequence MDGCEL

(Modifications: Met-1 = N-Formyl)

Storage Store at -20°C
CAS Number 881188-51-8
PubChem ID 44628955
InChI Key WFZPJYYCTSHDJI-ATIWLJMLSA-N
Smiles [H]N([C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)[C@H](CCSC)NC=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in PBS (pH 7.4)

Preparing Stock Solutions

The following data is based on the product molecular weight 694.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.44 mL 7.2 mL 14.39 mL
5 mM 0.29 mL 1.44 mL 2.88 mL
10 mM 0.14 mL 0.72 mL 1.44 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Säfholm et al (2008) The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin.Cancer Res. 14 6556 PMID: 18927296

Säfholm et al (2006) A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells. J.Biol.Chem. 281 2740 PMID: 16330545


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Keywords: Foxy5 wnt5a peptide mimetic Other Wnt Signaling

Citations for Foxy 5

Citations are publications that use Tocris products.

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Reviews

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Foxy 5

Wnt

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.

Protocols

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