Flutamide

Pricing Availability Delivery Time Qty
Cat.No. 4094 - Flutamide | C11H11F3N2O3 | CAS No. 13311-84-7
Description: Non-steroidal androgen receptor antagonist
Alternative Names: SCH 13521
Chemical Name: 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Non-steroidal antiandrogen; competitive antagonist of the androgen receptor. Blocks the biological activity of testosterone (Cat. No. 2822) in vivo.

Compound Libraries

Flutamide is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 276.21
Formula C11H11F3N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 13311-84-7
PubChem ID 3397
InChI Key MKXKFYHWDHIYRV-UHFFFAOYSA-N
Smiles CC(C)C(NC1=CC(C(F)(F)F)=C([N+]([O-])=O)C=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.62 100
ethanol 27.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 276.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.62 mL 18.1 mL 36.2 mL
5 mM 0.72 mL 3.62 mL 7.24 mL
10 mM 0.36 mL 1.81 mL 3.62 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the biological activity of the product.

Sufrin and Coffey (1976) Flutamide. Mechanism of action of a new nonsteroidal antiandrogen. Invest.Urol. 13 429 PMID: 1270239

Butcher et al (2007) Induction of human arylamine N-acetyltransferase type I by androgens in human prostate cancer cells. Cancer Res. 67 85 PMID: 17210686

Foster et al (2011) Drug safety is a barrier to the discovery and development of new androgen receptor antagonists. Prostate 71 480 PMID: 20878947


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Citations for Flutamide

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Literature in this Area

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