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A potent antagonist at NK1 receptors.
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Fujii et al (1992) Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist. FK888. Br.J.Pharmacol. 107 785 PMID: 1282073
Goso et al (1994) Comparison of tachykinin NK1 receptors in human IM9 and U373MG cells, using antagonist (FK 888, (±)-CP-96,345 and RP67580) binding. Eur.J.Pharmacol. 254 221 PMID: 7516885
Wang et al (1994) Investigation of the specificity of FK 888 as a tachykinin NK1 receptor antagonist. Br.J.Pharmacol. 111 1342 PMID: 7518299
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Keywords: FK 888, FK 888 supplier, selective, NK1, receptors, antagonists, tachykinins, neurokinins, Receptor, 0696, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.