Fisetin

Pricing Availability Delivery Time Qty
Cat.No. 5016 - Fisetin | C15H10O6 | CAS No. 528-48-3
Description: Naturally occuring flavonoid and antioxidant; neuroprotective
Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Naturally occuring flavonoid and antioxidant. Inhibits PI 3-K, Akt, mTOR and Cdk6. Displays antiproliferative activity in prostate cancer cells. Shown to activate ERK; exhibits neuroprotective activity in Huntington's disease models. Also a DNMT1 inhibitor.

Compound Libraries

Fisetin is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 286.24
Formula C15H10O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 528-48-3
PubChem ID 5281614
InChI Key XHEFDIBZLJXQHF-UHFFFAOYSA-N
Smiles OC2=C(C3=CC=C(O)C(O)=C3)OC1=CC(O)=CC=C1C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.62 100
ethanol 2.86 10

Preparing Stock Solutions

The following data is based on the product molecular weight 286.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.47 mL 34.94 mL
5 mM 0.7 mL 3.49 mL 6.99 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lu et al (2005) Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J.Med.Chem. 48 737 PMID: 15689157

Adhami et al (2012) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem.Pharmacol. 84 1277 PMID: 22842629

Haddad et al (2010) Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr.Cancer 62 668 PMID: 20574928

Maher et al (2011) ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum.Mol.Genet. 20 261 PMID: 20952447

Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018 PMID: 16037419


If you know of a relevant reference for Fisetin, please let us know.

Keywords: flavonoids antioxidants inhibitors inhibits PI 3-K kinase Akt mTOR Cdk6 antiproliferative cancer activates ERK neuroprotective Huntington's DNA Methyltransferases DNMT Antioxidants

1 Citation for Fisetin

Citations are publications that use Tocris products. Selected citations for Fisetin include:

Kim et al (2016) Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. PLoS Pathog 6 24933 PMID: 27112200


Do you know of a great paper that uses Fisetin from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for Fisetin

Protocols

TODO: Add Protocols