Fisetin

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Cat.No. 5016 - Fisetin | C15H10O6 | CAS No. 528-48-3
Description: Naturally occuring flavonoid and antioxidant; neuroprotective
Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Naturally occuring flavonoid and antioxidant. Inhibits PI 3-K, Akt, mTOR and Cdk6. Displays antiproliferative activity in prostate cancer cells. Shown to activate ERK; exhibits neuroprotective activity in Huntington's disease models. Also a DNMT1 inhibitor.

Compound Libraries

Fisetin is also offered as part of the Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 286.24
Formula C15H10O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 528-48-3
PubChem ID 5281614
InChI Key XHEFDIBZLJXQHF-UHFFFAOYSA-N
Smiles OC2=C(C3=CC=C(O)C(O)=C3)OC1=CC(O)=CC=C1C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.62 100
ethanol 2.86 10

Preparing Stock Solutions

The following data is based on the product molecular weight 286.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.49 mL 17.47 mL 34.94 mL
5 mM 0.7 mL 3.49 mL 6.99 mL
10 mM 0.35 mL 1.75 mL 3.49 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lu et al (2005) Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J.Med.Chem. 48 737 PMID: 15689157

Adhami et al (2012) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem.Pharmacol. 84 1277 PMID: 22842629

Haddad et al (2010) Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr.Cancer 62 668 PMID: 20574928

Maher et al (2011) ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum.Mol.Genet. 20 261 PMID: 20952447

Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018 PMID: 16037419


If you know of a relevant reference for Fisetin, please let us know.

Keywords: Fisetin, supplier, flavonoids, antioxidants, inhibitors, inhibits, PI, 3-K, kinase, Akt, mTOR, Cdk6, antiproliferative, cancer, activates, ERK, neuroprotective, Huntington's, DNA, Methyltransferases, DNMT, Antioxidants, DNA, Methyltransferases, Antioxidants, Tocris Bioscience

1 Citation for Fisetin

Citations are publications that use Tocris products. Selected citations for Fisetin include:

Kim et al (2016) Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. PLoS Pathog 6 24933 PMID: 27112200


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Literature in this Area

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New Product Guide (Spring/Summer 2017)

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