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FIIN 1 hydrochloride
Biological Activity for FIIN 1 hydrochloride
FIIN 1 hydrochloride is a potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).
Technical Data for FIIN 1 hydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FIIN 1 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for FIIN 1 hydrochloride
The following data is based on the product molecular weight 693.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.44 mL||7.21 mL||14.43 mL|
|5 mM||0.29 mL||1.44 mL||2.89 mL|
|10 mM||0.14 mL||0.72 mL||1.44 mL|
|50 mM||0.03 mL||0.14 mL||0.29 mL|
Product Datasheets for FIIN 1 hydrochloride
References for FIIN 1 hydrochloride
References are publications that support the biological activity of the product.
Zhou (2010) A structure-guided approach to creating covalent FGFR inhibitors. Chem.Biol. 17 285 PMID: 20338520
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Keywords: FIIN 1 hydrochloride, FIIN 1 hydrochloride supplier, FIIN1, hydrochloride, FGFR, fibroblast, growth, factors, receptors, irreversible, inhibits, inhibitors, PD173074, FGFR1, FGFR2, FGFR3, FGFR4, Flt-1, Flt-4, VEGFR2, 4002, Tocris Bioscience
1 Citation for FIIN 1 hydrochloride
Citations are publications that use Tocris products. Selected citations for FIIN 1 hydrochloride include:
Ji Yeon et al (2013) Modulation of bevacizumab-induced toxicity for cultured human corneal fibroblasts. Invest Ophthalmol Vis Sci 54 3922-31 PMID: 23640039
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.