FIIN 1 hydrochloride

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Cat.No. 4002 - FIIN 1 hydrochloride | C32H39Cl2N7O4 | CAS No. 1256152-35-8
Description: Potent, irreversible FGFR inhibitor
Chemical Name: N-(3-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-7-(4-(diethylamino)butylamino)-2-oxo-3,4-dihydropyrimido[4,5-d]pyrimidin-1(2H)-yl)methyl)phenyl)acrylamide
Purity: ≥96% (HPLC)
Datasheet
Citations
Reviews
Literature (7)

Biological Activity

Potent, irreversible FGFR inhibitor (Kd values are 2.8, 5.4, 6.9 and 120 nM for FGFR1, FGFR3, FGFR2 and FGFR4 respectively); acts at the ATP binding site. Also irreversibly inhibits Flt-1, Flt-4 and VEGFR-2 (Kd values are 32, 120 and 210 nM respectively); displays limited activity (Kd >500 nM) at other kinases. Exhibits antiproliferative activity in FGFR3- and FGFR1-transformed Ba/F3 cells (EC50 values are 10 and 14 nM respectively). Derived from the reversible FGFR inhibitor, PD 173074 (Cat. No. 3044).

Technical Data

M. Wt 693.06
Formula C32H39Cl2N7O4
Storage Store at -20°C
Purity ≥96% (HPLC)
CAS Number 1256152-35-8
PubChem ID 90488902
InChI Key IQLGDXNKTDKSMY-UHFFFAOYSA-N
Smiles CCN(CC)CCCCNC1=NC=C2C(N(CC3=CC=CC(NC(C=C)=O)=C3)C(N(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C2)=O)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 69.31 100
ethanol 69.31 100

Preparing Stock Solutions

The following data is based on the product molecular weight 693.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.44 mL 7.21 mL 14.43 mL
5 mM 0.29 mL 1.44 mL 2.89 mL
10 mM 0.14 mL 0.72 mL 1.44 mL
50 mM 0.03 mL 0.14 mL 0.29 mL

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References

References are publications that support the biological activity of the product.

Zhou (2010) A structure-guided approach to creating covalent FGFR inhibitors. Chem.Biol. 17 285 PMID: 20338520


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View all FGFR Inhibitors

Keywords: FIIN 1 hydrochloride, FIIN 1 hydrochloride supplier, FIIN1, hydrochloride, FGFR, fibroblast, growth, factors, receptors, irreversible, inhibits, inhibitors, PD173074, FGFR1, FGFR2, FGFR3, FGFR4, Flt-1, Flt-4, VEGFR2, 4002, Tocris Bioscience

Citations for FIIN 1 hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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