Fenoprofen calcium

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Cat.No. 6926 - Fenoprofen calcium | C15H13O3.0.5Ca | CAS No. 34597-40-5
Description: Positive allosteric modulator of MC3 receptors; exhibits biased signaling
Chemical Name: α-Methyl-3-phenoxybenzeneacetic acid hemicalcium salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Melanocortin 3 (MC3) receptor positive allosteric modulator (PAM; allosteric enhancer) (pEC50 = 8.69); decreases the EC50 of α-MSH at MC3R. Stimulates ERK1/2 activation at MC3-5R, with highest ERK1/2 activation observed at 3 and 10 μM for MC3R, 1 μM for MC4R, and 3 μM for MC5R. Exhibits biased signaling at MC3-5R, selectively activating ERK1/2 cascade but not canonical cAMP signaling. Antiarthritic.

Technical Data

M. Wt 261.31
Formula C15H13O3.0.5Ca
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 34597-40-5
PubChem ID 64746
InChI Key VHUXSAWXWSTUOD-UHFFFAOYSA-L
Smiles CC(C1=CC=CC(OC2=CC=CC=C2)=C1)C([O-])=O.CC(C3=CC=CC(OC4=CC=CC=C4)=C3)C([O-])=O.[Ca+2]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.13 100
ethanol 13.07 50

Preparing Stock Solutions

The following data is based on the product molecular weight 261.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.83 mL 19.13 mL 38.27 mL
5 mM 0.77 mL 3.83 mL 7.65 mL
10 mM 0.38 mL 1.91 mL 3.83 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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References

References are publications that support the biological activity of the product.

Yuan et al (2019) Fenoprofen-an old drug rediscovered as a biased allosteric enhancer for melanocortin receptors. ACS Chem.Neurosci. 10 1066 PMID: 30168706

Montero-Melendez et al (2017) Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3 Cell Mol.Life Sci. 74 1335 PMID: 27853832


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Keywords: Fenoprofen calcium, Fenoprofen calcium supplier, 71720-56-4, 71720564, Melanocortin, 3, MC3, receptor, positive, allosteric, modulators, PAMs, enhancers, biased, signaling, antiarthritic, anti-inflamatory, NSAID, Receptors, 6926, Tocris Bioscience

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