Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewFenoprofen calcium
Description: Positive allosteric modulator of MC3 receptors; exhibits biased signaling
Chemical Name: α-Methyl-3-phenoxybenzeneacetic acid hemicalcium salt
Purity: ≥98% (HPLC)
Biological Activity for Fenoprofen calcium
Fenoprofen calcium is a melanocortin 3 (MC3) receptor positive allosteric modulator (PAM; allosteric enhancer) (pEC50 = 8.69); decreases the EC50 of α-MSH at MC3R. Stimulates ERK1/2 activation at MC3-5R, with highest ERK1/2 activation observed at 3 and 10 μM for MC3R, 1 μM for MC4R, and 3 μM for MC5R. Exhibits biased signaling at MC3-5R, selectively activating ERK1/2 cascade but not canonical cAMP signaling. Antiarthritic.
Technical Data for Fenoprofen calcium
| M. Wt | 261.31 |
| Formula | C15H13O3.0.5Ca |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 34597-40-5 |
| PubChem ID | 64746 |
| InChI Key | VHUXSAWXWSTUOD-UHFFFAOYSA-L |
| Smiles | CC(C1=CC=CC(OC2=CC=CC=C2)=C1)C([O-])=O.CC(C3=CC=CC(OC4=CC=CC=C4)=C3)C([O-])=O.[Ca+2] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fenoprofen calcium
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.13 | 100 | |
| ethanol | 13.07 | 50 |
Preparing Stock Solutions for Fenoprofen calcium
The following data is based on the product molecular weight 261.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.83 mL | 19.13 mL | 38.27 mL |
| 5 mM | 0.77 mL | 3.83 mL | 7.65 mL |
| 10 mM | 0.38 mL | 1.91 mL | 3.83 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.77 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Fenoprofen calcium
References for Fenoprofen calcium
References are publications that support the biological activity of the product.
Yuan et al (2019) Fenoprofen-an old drug rediscovered as a biased allosteric enhancer for melanocortin receptors. ACS Chem.Neurosci. 10 1066 PMID: 30168706
Montero-Melendez et al (2017) Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3 Cell Mol.Life Sci. 74 1335 PMID: 27853832
If you know of a relevant reference for Fenoprofen calcium, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Fenoprofen calcium, Fenoprofen calcium supplier, 71720-56-4, 71720564, Melanocortin, 3, MC3, receptor, positive, allosteric, modulators, PAMs, enhancers, biased, signaling, antiarthritic, anti-inflamatory, NSAID, Receptors, 6926, Tocris Bioscience
Citations for Fenoprofen calcium
Citations are publications that use Tocris products.
Currently there are no citations for Fenoprofen calcium. Do you know of a great paper that uses Fenoprofen calcium from Tocris? Please let us know.
Reviews for Fenoprofen calcium
There are currently no reviews for this product. Be the first to review Fenoprofen calcium and earn rewards!
Have you used Fenoprofen calcium?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.