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Description: PPARα agonist
Chemical Name: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
Purity: ≥99% (HPLC)
Citations (5)

Biological Activity for Fenofibrate

Fenofibrate is a PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.

Compound Libraries for Fenofibrate

Fenofibrate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Fenofibrate

M. Wt 360.83
Formula C20H21ClO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 49562-28-9
PubChem ID 3339
Smiles CC(C)OC(C(C)(C)OC(C=C2)=CC=C2C(C1=CC=C(Cl)C=C1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Fenofibrate

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 36.08 100
ethanol 36.08 100

Preparing Stock Solutions for Fenofibrate

The following data is based on the product molecular weight 360.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.86 mL 27.71 mL
5 mM 0.55 mL 2.77 mL 5.54 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets for Fenofibrate

Certificate of Analysis / Product Datasheet
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References for Fenofibrate

References are publications that support the biological activity of the product.

Mandard et al (2004) The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofi. treatment. J.Biol.Chem. 279 34411 PMID: 15190076

Park et al (2006) PPARα agonist fenofi. improves diabetic nephropathy in db/db mice. Kidney Int. 69 1511 PMID: 16672921

Balakumar et al (2011) Pleiotropic actions of fenofi. on the heart. Pharmacol.Res. 63 8 PMID: 21093591

If you know of a relevant reference for Fenofibrate, please let us know.

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Keywords: Fenofibrate, Fenofibrate supplier, peroxisome, proliferator-activated, receptors, pparalpha, PPARa, PPARα, agonists, PPARalpha, Receptors, 4113, Tocris Bioscience

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