PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.77 mL||13.86 mL||27.71 mL|
|5 mM||0.55 mL||2.77 mL||5.54 mL|
|10 mM||0.28 mL||1.39 mL||2.77 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Mandard et al (2004) The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J.Biol.Chem. 279 34411 PMID: 15190076
Park et al (2006) PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int. 69 1511 PMID: 16672921
Balakumar et al (2011) Pleiotropic actions of fenofibrate on the heart. Pharmacol.Res. 63 8 PMID: 21093591
If you know of a relevant reference for Fenofibrate, please let us know.
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Keywords: peroxisome proliferator-activated receptors pparalpha PPARa PPARα agonists PPARalpha Receptors
3 Citations for Fenofibrate
Citations are publications that use Tocris products. Selected citations for Fenofibrate include:
Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated Invest Ophthalmol Vis Sci 339 886 PMID: 21896918
Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. J Pharmacol Exp Ther 10 e0120295 PMID: 25811180
Redlich et al (2014) Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections. PLoS One 11 108 PMID: 24927796
Do you know of a great paper that uses Fenofibrate from Tocris? If so please let us know.