Fenofibrate

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Cat.No. 4113 - Fenofibrate | C20H21ClO4 | CAS No. 49562-28-9
Description: PPARα agonist
Chemical Name: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (3)

Biological Activity

PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.

Compound Libraries

Fenofibrate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 360.83
Formula C20H21ClO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 49562-28-9
PubChem ID 3339
InChI Key YMTINGFKWWXKFG-UHFFFAOYSA-N
Smiles CC(C)OC(C(C)(C)OC(C=C2)=CC=C2C(C1=CC=C(Cl)C=C1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.08 100
ethanol 36.08 100

Preparing Stock Solutions

The following data is based on the product molecular weight 360.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.86 mL 27.71 mL
5 mM 0.55 mL 2.77 mL 5.54 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Mandard et al (2004) The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofi. treatment. J.Biol.Chem. 279 34411 PMID: 15190076

Park et al (2006) PPARα agonist fenofi. improves diabetic nephropathy in db/db mice. Kidney Int. 69 1511 PMID: 16672921

Balakumar et al (2011) Pleiotropic actions of fenofi. on the heart. Pharmacol.Res. 63 8 PMID: 21093591


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Keywords: Fenofibrate, Fenofibrate supplier, peroxisome, proliferator-activated, receptors, pparalpha, PPARa, PPARα, agonists, PPARalpha, Receptors, 4113, Tocris Bioscience

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Literature in this Area

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