Fenofibrate

Pricing Availability Delivery Time Qty
Cat.No. 4113 - Fenofibrate | C20H21ClO4 | CAS No. 49562-28-9
Description: PPARα agonist
Chemical Name: 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

PPARα agonist; hypolipidemic. Attenuates insulin resistance and increases high-density lipoprotein-cholesterol in db/db mice.

Compound Libraries

Fenofibrate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 360.83
Formula C20H21ClO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 49562-28-9
PubChem ID 3339
InChI Key YMTINGFKWWXKFG-UHFFFAOYSA-N
Smiles CC(C)OC(C(C)(C)OC(C=C2)=CC=C2C(C1=CC=C(Cl)C=C1)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.08 100
ethanol 36.08 100

Preparing Stock Solutions

The following data is based on the product molecular weight 360.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.86 mL 27.71 mL
5 mM 0.55 mL 2.77 mL 5.54 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Mandard et al (2004) The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J.Biol.Chem. 279 34411 PMID: 15190076

Park et al (2006) PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice. Kidney Int. 69 1511 PMID: 16672921

Balakumar et al (2011) Pleiotropic actions of fenofibrate on the heart. Pharmacol.Res. 63 8 PMID: 21093591


If you know of a relevant reference for Fenofibrate, please let us know.

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Keywords: peroxisome proliferator-activated receptors pparalpha PPARa PPARα agonists PPARalpha Receptors

3 Citations for Fenofibrate

Citations are publications that use Tocris products. Selected citations for Fenofibrate include:

Bumpus and Johnson (2011) 5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated Invest Ophthalmol Vis Sci 339 886 PMID: 21896918

Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. J Pharmacol Exp Ther 10 e0120295 PMID: 25811180

Redlich et al (2014) Palmitoylethanolamide stimulates phagocytosis of Escherichia coli K1 by macrophages and increases the resistance of mice against infections. PLoS One 11 108 PMID: 24927796


Do you know of a great paper that uses Fenofibrate from Tocris? If so please let us know.

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Pathways for Fenofibrate

Protocols

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