Febuxostat

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Cat.No. 4427 - Febuxostat | C16H16N2O3S | CAS No. 144060-53-7
Description: Xanthine oxidase inhibitor
Alternative Names: TEI 6720, TMX 67
Chemical Name: 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Non-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.

Compound Libraries

Febuxostat is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 316.37
Formula C16H16N2O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 144060-53-7
PubChem ID 134018
InChI Key BQSJTQLCZDPROO-UHFFFAOYSA-N
Smiles CC1=C(C(O)=O)SC(C2=CC(C#N)=C(OCC(C)C)C=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.73 75
ethanol 15.82 50

Preparing Stock Solutions

The following data is based on the product molecular weight 316.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.21 mL 21.07 mL 42.14 mL
3.75 mM 0.84 mL 4.21 mL 8.43 mL
7.5 mM 0.42 mL 2.11 mL 4.21 mL
37.5 mM 0.08 mL 0.42 mL 0.84 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Osada et al (1993) Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 241 183 PMID: 8243554

Xu et al (2008) Xanthine oxidase inhibition with febux. attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 14 746 PMID: 18995179

Okamoto et al (2003) An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 278 1848 PMID: 12421831


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Keywords: Febuxostat, Febuxostat supplier, TMX67, TEI6720, Febuxostat, xanthine, oxidase, oxidoreductase, inhibitors, inhibits, TEI, 6720, TMX, 67, Other, Oxygenases/Oxidases, 4427, Tocris Bioscience

2 Citations for Febuxostat

Citations are publications that use Tocris products. Selected citations for Febuxostat include:

Tremere et al (2009) OE shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression. J Neurosci 29 5949 PMID: 19420261

Konishi et al (2015) Febuxostat improves outcome in a rat model of cancer cachexia. Front Cell Neurosci 6 174 PMID: 26136193


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Literature in this Area

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