Febuxostat

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Cat.No. 4427 - Febuxostat | C16H16N2O3S | CAS No. 144060-53-7
Description: Xanthine oxidase inhibitor
Alternative Names: TEI 6720, TMX 67
Chemical Name: 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Non-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.

Compound Libraries

Febuxostat is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 316.37
Formula C16H16N2O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 144060-53-7
PubChem ID 134018
InChI Key BQSJTQLCZDPROO-UHFFFAOYSA-N
Smiles CC1=C(C(O)=O)SC(C2=CC(C#N)=C(OCC(C)C)C=C2)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.73 75
ethanol 15.82 50

Preparing Stock Solutions

The following data is based on the product molecular weight 316.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.16 mL 15.8 mL 31.61 mL
5 mM 0.63 mL 3.16 mL 6.32 mL
10 mM 0.32 mL 1.58 mL 3.16 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Osada et al (1993) Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 241 183 PMID: 8243554

Xu et al (2008) Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 14 746 PMID: 18995179

Okamoto et al (2003) An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 278 1848 PMID: 12421831


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Keywords: Febuxostat, supplier, TMX67, TEI6720, Febuxostat, xanthine, oxidase, oxidoreductase, inhibitors, inhibits, TEI, 6720, TMX, 67, Other, Oxygenases/Oxidases, Tocris Bioscience

1 Citation for Febuxostat

Citations are publications that use Tocris products. Selected citations for Febuxostat include:

Konishi et al (2015) Febuxostat improves outcome in a rat model of cancer cachexia. Front Cell Neurosci 6 174 PMID: 26136193


Do you know of a great paper that uses Febuxostat from Tocris? If so please let us know.

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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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Pathways for Febuxostat

Protocols

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