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Non-purine inhibitor of xanthine oxidase (Ki = 1.2 nM). Binds to a channel leading to the enzyme active site; obstructs substrate binding.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 316.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||4.21 mL||21.07 mL||42.14 mL|
|3.75 mM||0.84 mL||4.21 mL||8.43 mL|
|7.5 mM||0.42 mL||2.11 mL||4.21 mL|
|37.5 mM||0.08 mL||0.42 mL||0.84 mL|
References are publications that support the biological activity of the product.
Osada et al (1993) Hypouricemic effect of the novel xanthine oxidase inhibitor, TEI-6720, in rodents. Eur.J.Pharmacol. 241 183 PMID: 8243554
Xu et al (2008) Xanthine oxidase inhibition with febux. attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice. J.Card.Fail. 14 746 PMID: 18995179
Okamoto et al (2003) An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition. J.Biol.Chem. 278 1848 PMID: 12421831
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Keywords: Febuxostat, Febuxostat supplier, TMX67, TEI6720, Febuxostat, xanthine, oxidase, oxidoreductase, inhibitors, inhibits, TEI, 6720, TMX, 67, Other, Oxygenases/Oxidases, 4427, Tocris Bioscience
2 Citations for Febuxostat
Citations are publications that use Tocris products. Selected citations for Febuxostat include:
Tremere et al (2009) OE shapes auditory processing in the adult brain by regulating inhibitory transmission and plasticity-associated gene expression. J Neurosci 29 5949 PMID: 19420261
Konishi et al (2015) Febuxostat improves outcome in a rat model of cancer cachexia. Front Cell Neurosci 6 174 PMID: 26136193
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