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Description: GLUT1/GLUT4 inhibitor; also Fas-sensitizer
Chemical Name: N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for Fasentin

Fasentin is a GLUT1 and GLUT4 inhibitor (IC50 = 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC50 = 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.

Technical Data for Fasentin

M. Wt 279.64
Formula C11H9ClF3NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 392721-37-8
PubChem ID 879520
Smiles CC(CC(NC1=CC(C(F)(F)F)=C(C=C1)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Fasentin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.96 100
ethanol 27.96 100

Preparing Stock Solutions for Fasentin

The following data is based on the product molecular weight 279.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.88 mL 35.76 mL
5 mM 0.72 mL 3.58 mL 7.15 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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References for Fasentin

References are publications that support the biological activity of the product.

Schimmer et al (2006) Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer.Res. 66 2367 PMID: 16489043

Wood et al (2008) A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol.Cancer.Ther. 7 3546 PMID: 19001437

Granchi et al (2016) Anticancer agents interacting with membrane glucose transporters. Med.Chem.Comm. 7 1716 PMID: 28042452

If you know of a relevant reference for Fasentin, please let us know.

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Keywords: Fasentin, Fasentin supplier, Fasentin, Inhibitors, Inhibits, Glucose, transporter, GLUT1, GLUT4, Fas-sensitizer, apoptosis, TNF, Transporters, 6100, Tocris Bioscience

Citations for Fasentin

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.