Fasentin

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Cat.No. 6100 - Fasentin | C11H9ClF3NO2 | CAS No. 392721-37-8
Description: GLUT1/GLUT4 inhibitor; also Fas-sensitizer
Chemical Name: N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

GLUT1 and GLUT4 inhibitor (IC50 = 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC50 = 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.

Technical Data

M. Wt 279.64
Formula C11H9ClF3NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 392721-37-8
PubChem ID 879520
InChI Key GNYIJZMBLZXJEJ-UHFFFAOYSA-N
Smiles CC(CC(NC1=CC(C(F)(F)F)=C(C=C1)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.96 100
ethanol 27.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 279.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.88 mL 35.76 mL
5 mM 0.72 mL 3.58 mL 7.15 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Schimmer et al (2006) Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer.Res. 66 2367 PMID: 16489043

Wood et al (2008) A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol.Cancer.Ther. 7 3546 PMID: 19001437

Granchi et al (2016) Anticancer agents interacting with membrane glucose transporters. Med.Chem.Comm. 7 1716 PMID: 8042452


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Keywords: Fasentin, supplier, Fasentin, Inhibitors, Inhibits, Glucose, transporter, GLUT1, GLUT4, Fas-sensitizer, apoptosis, TNF, Glucose, Transporters, Glucose, Transporters, Tocris Bioscience

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis