Exo1

Pricing Availability Delivery Time Qty
Cat.No. 1850 - Exo1 | C15H12FNO3 | CAS No. 461681-88-9
Description: Inhibits Golgi-ER traffic; blocks exocytosis
Chemical Name: 2-[(4-Fluorobenzoyl)amino]-benzoic acid methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC50 ~ 20 mM). Has similar, but not identical, action to brefeldin A (Cat. No. 1231).

Compound Libraries

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Technical Data

M. Wt 273.26
Formula C15H12FNO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 461681-88-9
PubChem ID 310557
InChI Key KIAPWMKFHIKQOZ-UHFFFAOYSA-N
Smiles COC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 6.83 25 with gentle warming
DMSO 27.33 100

Preparing Stock Solutions

The following data is based on the product molecular weight 273.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Feng et al (2003) Exo1: A new chemical inhibitor of the exocytic pathway. Proc.Natl.Acad.Sci.U.S.A. 100 6469 PMID: 12738886


If you know of a relevant reference for Exo1, please let us know.

Keywords: Exo1, Exo1 supplier, inhibitors, inhibits, Golgi-ER, traffic, blocks, exocytosis, Golgi, ADP-ribosylation, factor, ARF1, GTPase, Translocation,, Exocytosis, &, Endocytosis, 1850, Tocris Bioscience

2 Citations for Exo1

Citations are publications that use Tocris products. Selected citations for Exo1 include:

Eppler et al (2017) Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion. PLoS One 12 e0172443 PMID: 28273099

Greene et al (2017) XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits. J.Pharmacol.Exp.Ther. 362 177 PMID: 28483800


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