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Cat.No. 1850 - Exo1 | C15H12FNO3 | CAS No. 461681-88-9
Description: Inhibits Golgi-ER traffic; blocks exocytosis
Chemical Name: 2-[(4-Fluorobenzoyl)amino]-benzoic acid methyl ester
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity for Exo1

Exo1 is a reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC50 ~ 20 μM). Has similar, but not identical, action to brefeldin A (Cat. No. 1231).

Technical Data for Exo1

M. Wt 273.26
Formula C15H12FNO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 461681-88-9
PubChem ID 310557
Smiles COC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Exo1

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 6.83 25 with gentle warming
DMSO 27.33 100

Preparing Stock Solutions for Exo1

The following data is based on the product molecular weight 273.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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References for Exo1

References are publications that support the biological activity of the product.

Feng et al (2003) Exo1: A new chemical inhibitor of the exocytic pathway. Proc.Natl.Acad.Sci.U.S.A. 100 6469 PMID: 12738886

If you know of a relevant reference for Exo1, please let us know.

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Keywords: Exo1, Exo1 supplier, inhibitors, inhibits, Golgi-ER, traffic, blocks, exocytosis, Golgi, ADP-ribosylation, factor, ARF1, GTPase, Exocytosis, 1850, Tocris Bioscience

2 Citations for Exo1

Citations are publications that use Tocris products. Selected citations for Exo1 include:

Eppler et al (2017) Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion. PLoS One 12 e0172443 PMID: 28273099

Greene et al (2017) XE991 and Linopirdine are state-dependent inhibitors for Kv7/KCNQ channels that favor activated single subunits. J.Pharmacol.Exp.Ther. 362 177 PMID: 28483800

Do you know of a great paper that uses Exo1 from Tocris? Please let us know.

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