Exo1

Pricing Availability Delivery Time Qty
Cat.No. 1850 - Exo1 | C15H12FNO3 | CAS No. 461681-88-9
Description: Inhibits Golgi-ER traffic; blocks exocytosis
Chemical Name: 2-[(4-Fluorobenzoyl)amino]-benzoic acid methyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Modifies Golgi ADP-ribosylation factor (ARF)1 GTPase activity and inhibits exocytosis (IC50 ~ 20 mM). Has similar, but not identical, action to brefeldin A (Cat. No. 1231).

Compound Libraries

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Technical Data

M. Wt 273.26
Formula C15H12FNO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 461681-88-9
PubChem ID 310557
InChI Key KIAPWMKFHIKQOZ-UHFFFAOYSA-N
Smiles COC(=O)C1=CC=CC=C1NC(=O)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.33 100
ethanol 6.83 25mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 273.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.66 mL 18.3 mL 36.6 mL
5 mM 0.73 mL 3.66 mL 7.32 mL
10 mM 0.37 mL 1.83 mL 3.66 mL
50 mM 0.07 mL 0.37 mL 0.73 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Feng et al (2003) Exo1: A new chemical inhibitor of the exocytic pathway. Proc.Natl.Acad.Sci.U.S.A. 100 6469 PMID: 12738886


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Keywords: inhibitors inhibits Golgi-ER traffic blocks exocytosis Golgi ADP-ribosylation factor ARF1 GTPase Translocation, Exocytosis & Endocytosis

Citations for Exo1

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
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Pathways for Exo1

Protocols

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