Ethyl LipotF

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Cat.No. 5950 - Ethyl LipotF | C19H19N3O4 | CAS No. 1808089-27-1
Description: Selective FTO inhibitor
Chemical Name: Ethyl (E)-4-(2-(4-benzylnicotinoyl)hydrazinyl)-4-oxobut-2-enoate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Selective FTO inhibitor (IC50 = 0.81 μM). Exhibits >30-fold selectivity for FTO over ALKBH2, 3 and 5 and >100-fold selectivity over PHD2 and JMJD2A. Increases levels of modified N6-methyladenosine (m6A) in HeLa cells in a concentration-dependent manner.

Technical Data

M. Wt 353.38
Formula C19H19N3O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1808089-27-1
InChI Key XUKLGMSFWAEOPR-CMDGGOBGSA-N
Smiles O=C(NNC(/C=C/C(OCC)=O)=O)C1=C(CC2=CC=CC=C2)C=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 7.07 20
DMSO 35.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 353.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.83 mL 14.15 mL 28.3 mL
5 mM 0.57 mL 2.83 mL 5.66 mL
10 mM 0.28 mL 1.41 mL 2.83 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Toh et al (2015) A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO. Chem.Sci. 6 112 PMID: 28553460

Cheong et al (2018) A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N6-methyladenosine demethylase activity in cells. Chem.Sci. 9 7174 PMID: 30288236


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Keywords: Ethyl LipotF, Ethyl LipotF supplier, FTO, inhibitors, inhibits, fat, mass, and, obesity, associated, protein, mRNA, N6-methyladenine, demethylase, ALKBH9, α, alpha-ketoglutarate-dependent, dioxygenase, M6A, Other, Oxygenases/Oxidases, 5950, Tocris Bioscience

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