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Biological Activity for Ethyl LipotF
Ethyl LipotF is a selective FTO inhibitor (IC50 = 0.81 μM). Exhibits >30-fold selectivity for FTO over ALKBH2, 3 and 5 and >100-fold selectivity over PHD2 and JMJD2A. Increases levels of modified N6-methyladenosine (m6A) in HeLa cells in a concentration-dependent manner.
Technical Data for Ethyl LipotF
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ethyl LipotF
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Ethyl LipotF
The following data is based on the product molecular weight 353.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.83 mL||14.15 mL||28.3 mL|
|5 mM||0.57 mL||2.83 mL||5.66 mL|
|10 mM||0.28 mL||1.41 mL||2.83 mL|
|50 mM||0.06 mL||0.28 mL||0.57 mL|
References for Ethyl LipotF
References are publications that support the biological activity of the product.
Toh et al (2015) A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO. Chem.Sci. 6 112 PMID: 28553460
Cheong et al (2018) A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N6-methyladenosine demethylase activity in cells. Chem.Sci. 9 7174 PMID: 30288236
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Keywords: Ethyl LipotF, Ethyl LipotF supplier, FTO, inhibitors, inhibits, fat, mass, and, obesity, associated, protein, mRNA, N6-methyladenine, demethylase, ALKBH9, α, alpha-ketoglutarate-dependent, dioxygenase, M6A, Other, Oxygenases/Oxidases, 5950, Tocris Bioscience
Citations for Ethyl LipotF
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