Etazolate hydrochloride

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Cat.No. 0438 - Etazolate hydrochloride | C14H19N5O2.HCl | CAS No. 35838-58-5
Description: PDE4 inhibitor
Chemical Name: 1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo-[3,4-b]-pyridine-5-carboxylic acid, ethyl ester hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Phosphodiesterase inhibitor, selective for PDE4 (IC50 = 2.0 μM).

Technical Data

M. Wt 325.8
Formula C14H19N5O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 35838-58-5
PubChem ID 37274
InChI Key GQJUGJHJUZSJLZ-UHFFFAOYSA-N
Smiles CCN2C1=NC=C(C(OCC)=O)C(NN=C(C)C)=C1C=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.58 100
water 50

Preparing Stock Solutions

The following data is based on the product molecular weight 325.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.35 mL 30.69 mL
5 mM 0.61 mL 3.07 mL 6.14 mL
10 mM 0.31 mL 1.53 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ahluwalia and Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19 PMID: 1848733

Chesin et al (1972) 1-Ethyl-4-(isopropylidenehydrazinol-H-pyrazolo-(3,4-b)-pyridin-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009) - potent new inhibitor of cyclic 3'5-nucleotide phosphodiesterase. Biochem.Pharmacol. 21 2443 PMID: 4345859

Rhoads (1982) Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction. Biochem.Pharmacol. 31 665 PMID: 6177320


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Keywords: Etazolate hydrochloride, supplier, PDE4, inhibitors, inhibits, PDE, Phosphodiesterases, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience

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