Etazolate hydrochloride

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Cat.No. 0438 - Etazolate hydrochloride | C14H19N5O2.HCl | CAS No. 35838-58-5
Description: PDE4 inhibitor
Chemical Name: 1-Ethyl-4-[(1-methylethylidene)hydrazino]-1H-pyrazolo-[3,4-b]-pyridine-5-carboxylic acid, ethyl ester hydrochloride
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity

Phosphodiesterase inhibitor, selective for PDE4 (IC50 = 2.0 μM).

Technical Data

M. Wt 325.8
Formula C14H19N5O2.HCl
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 35838-58-5
PubChem ID 37274
Smiles CCN2C1=NC=C(C(OCC)=O)C(NN=C(C)C)=C1C=N2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 50
DMSO 32.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 325.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.35 mL 30.69 mL
5 mM 0.61 mL 3.07 mL 6.14 mL
10 mM 0.31 mL 1.53 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Ahluwalia and Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19 PMID: 1848733

Chesin et al (1972) 1-Ethyl-4-(isopropylidenehydrazinol-H-pyrazolo-(3,4-b)-pyridin-5-carboxylic acid, ethyl ester, hydrochloride (SQ 20009) - potent new inhibitor of cyclic 3'5-nucleotide phosphodiesterase. Biochem.Pharmacol. 21 2443 PMID: 4345859

Rhoads (1982) Selective inhibition of cyclic AMP and cyclic GMP phosphodiesterases of cardiac nuclear fraction. Biochem.Pharmacol. 31 665 PMID: 6177320

If you know of a relevant reference for Etazolate hydrochloride, please let us know.

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