ERB 041

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Cat.No. 4276 - ERB 041 | C15H10FNO3 | CAS No. 524684-52-4
Description: Potent ERβ agonist
Chemical Name: 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 271.24
Formula C15H10FNO3
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 524684-52-4
PubChem ID 5326893
InChI Key FCXYSEXZEGPLGG-DHDCSXOGSA-N
Smiles C=CC1=C2C(N=C(C3=CC=C(O)C(F)=C3)O2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.12 100
ethanol 27.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 271.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.43 mL 36.87 mL
5 mM 0.74 mL 3.69 mL 7.37 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Harris et al (2003) Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 144 4241 PMID: 14500559

Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246

Cvoro et al (2008) Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol. 180 630 PMID: 18097065


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Keywords: pfizer ERB041 potent erb erbeta erγ estrogen receptors agonists selective Estrogen and Related Receptors

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Literature in this Area

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Pathways for ERB 041

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.

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