Potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 271.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.69 mL||18.43 mL||36.87 mL|
|5 mM||0.74 mL||3.69 mL||7.37 mL|
|10 mM||0.37 mL||1.84 mL||3.69 mL|
|50 mM||0.07 mL||0.37 mL||0.74 mL|
References are publications that support the biological activity of the product.
Harris et al (2003) Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 144 4241 PMID: 14500559
Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246
Cvoro et al (2008) Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol. 180 630 PMID: 18097065
If you know of a relevant reference for ERB 041, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ERB 041, ERB 041 supplier, pfizer, ERB041, potent, erb, erbeta, erγ, estrogen, receptors, agonists, selective, Estrogen, and, Related, Receptors, 4276, Tocris Bioscience
1 Citation for ERB 041
Citations are publications that use Tocris products. Selected citations for ERB 041 include:
Cortes et al (2018) GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Rep. e46556 PMID: 30538117
Do you know of a great paper that uses ERB 041 from Tocris? Please let us know.
Reviews for ERB 041
There are currently no reviews for this product. Be the first to review ERB 041 and earn rewards!
Have you used ERB 041?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.