ERB 041

Pricing Availability   Qty
Description: Potent ERβ agonist
Chemical Name: 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol
Purity: ≥98% (HPLC)
Citations (2)
Pathways (1)

Biological Activity for ERB 041

ERB 041 is a potent ERβ agonist; displays >200-fold selectivity for ERβ over ERα (IC50 values are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for ERB 041

M. Wt 271.24
Formula C15H10FNO3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 524684-52-4
PubChem ID 5326893
Smiles C=CC1=C2C(N=C(C3=CC=C(O)C(F)=C3)O2)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ERB 041

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 27.12 100
ethanol 27.12 100

Preparing Stock Solutions for ERB 041

The following data is based on the product molecular weight 271.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.69 mL 18.43 mL 36.87 mL
5 mM 0.74 mL 3.69 mL 7.37 mL
10 mM 0.37 mL 1.84 mL 3.69 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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Product Datasheets for ERB 041

Certificate of Analysis / Product Datasheet
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References for ERB 041

References are publications that support the biological activity of the product.

Harris et al (2003) Evaluaton of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 144 4241 PMID: 14500559

Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-β ligands. J.Med.Chem. 47 5021 PMID: 15456246

Cvoro et al (2008) Selective estrogen receptor-γ agonists repress transcription of proinflammatory genes. J.Immunol. 180 630 PMID: 18097065

If you know of a relevant reference for ERB 041, please let us know.

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2 Citations for ERB 041

Citations are publications that use Tocris products. Selected citations for ERB 041 include:

Gang et al (2021) Estrogen Receptor β Contributes to Both Hypertension and Hypothalamic Plasticity in a Mouse Model of Peri-Menopause. J Neurosci 41 5190-5205 PMID: 33941651

Cortes et al (2018) GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment. EMBO Rep. e46556 PMID: 30538117

Do you know of a great paper that uses ERB 041 from Tocris? Please let us know.

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Pathways for ERB 041

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.