Home / Pharmacology / Enzymes / Phosphodiesterases / Phosphodiesterase Inhibitors / Eggmanone

Eggmanone

Cat. No. 5695 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 5695 - Eggmanone | C20H20N2O2S3 | CAS No. 505068-32-6
Description: Potent and selective PDE4 inhibitor; suppresses hedgehog signaling
Chemical Name: 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1 and Ptc1.

Technical Data

M. Wt 416.58
Formula C20H20N2O2S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 505068-32-6
PubChem ID 1158635
InChI Key XAKJIQPEGSCYIP-UHFFFAOYSA-N
Smiles CC(CN1C(C2=C(N=C1SCC(C3=CC=CS3)=O)SC4=C2CCCC4)=O)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.33 20

Preparing Stock Solutions

The following data is based on the product molecular weight 416.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12 mL 60.01 mL 120.02 mL
1 mM 2.4 mL 12 mL 24 mL
2 mM 1.2 mL 6 mL 12 mL
10 mM 0.24 mL 1.2 mL 2.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Williams et al (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11 43 PMID: 25818300

If you know of a relevant reference for Eggmanone, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: Eggmanone, Eggmanone supplier, Potent, selective, phosphodiesterases, PDE, 4, inhibitors, inhibits, hedgehog, signallling, Phosphodiesterases, Hedgehog, Signaling, 5695, Tocris Bioscience

1 Citation for Eggmanone

Citations are publications that use Tocris products. Selected citations for Eggmanone include:

Kan et al (2018) Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification. Bone 109 71 PMID: 28645539

Do you know of a great paper that uses Eggmanone from Tocris? Please let us know.

Reviews for Eggmanone

There are currently no reviews for this product. Be the first to review Eggmanone and earn rewards!

Have you used Eggmanone?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.