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Eggmanone

Cat. No. 5695 Submit a Review Datasheet / COA / SDS
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Cat.No. 5695 - Eggmanone | C20H20N2O2S3 | CAS No. 505068-32-6
Description: Potent and selective PDE4 inhibitor; suppresses hedgehog signaling
Chemical Name: 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1 and Ptc1.

Technical Data

M. Wt 416.58
Formula C20H20N2O2S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 505068-32-6
PubChem ID 1158635
InChI Key XAKJIQPEGSCYIP-UHFFFAOYSA-N
Smiles CC(CN1C(C2=C(N=C1SCC(C3=CC=CS3)=O)SC4=C2CCCC4)=O)=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.33 20

Preparing Stock Solutions

The following data is based on the product molecular weight 416.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 12 mL 60.01 mL 120.02 mL
1 mM 2.4 mL 12 mL 24 mL
2 mM 1.2 mL 6 mL 12 mL
10 mM 0.24 mL 1.2 mL 2.4 mL

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References

References are publications that support the biological activity of the product.

Williams et al (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11 43 PMID: 25818300

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