Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewEggmanone
Description: Potent and selective PDE4 inhibitor; suppresses hedgehog signaling
Chemical Name: 5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
Purity: ≥98% (HPLC)
Biological Activity for Eggmanone
Eggmanone is a potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1 and Ptc1.
Technical Data for Eggmanone
| M. Wt | 416.58 |
| Formula | C20H20N2O2S3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 505068-32-6 |
| PubChem ID | 1158635 |
| InChI Key | XAKJIQPEGSCYIP-UHFFFAOYSA-N |
| Smiles | CC(CN1C(C2=C(N=C1SCC(C3=CC=CS3)=O)SC4=C2CCCC4)=O)=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Eggmanone
References for Eggmanone
References are publications that support the biological activity of the product.
Williams et al (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11 43 PMID: 25818300
View Related Products by Target
View Related Products by Product Action
Keywords: Eggmanone, Eggmanone supplier, Potent, selective, phosphodiesterases, PDE, 4, inhibitors, inhibits, hedgehog, signallling, Phosphodiesterases, Hedgehog, Signaling, 5695, Tocris Bioscience
1 Citation for Eggmanone
Citations are publications that use Tocris products. Selected citations for Eggmanone include:
Kan et al (2018) Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification. Bone 109 71 PMID: 28645539
Reviews for Eggmanone
There are currently no reviews for this product. Be the first to review Eggmanone and earn rewards!
Have you used Eggmanone?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image