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Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1 and Ptc1.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 416.58. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12 mL||60.01 mL||120.02 mL|
|1 mM||2.4 mL||12 mL||24 mL|
|2 mM||1.2 mL||6 mL||12 mL|
|10 mM||0.24 mL||1.2 mL||2.4 mL|
References are publications that support the biological activity of the product.
Williams et al (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11 43 PMID: 25818300
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Keywords: Eggmanone, Eggmanone supplier, Potent, selective, phosphodiesterases, PDE, 4, inhibitors, inhibits, hedgehog, signallling, Phosphodiesterases, Hedgehog, Signaling, 5695, Tocris Bioscience
1 Citation for Eggmanone
Citations are publications that use Tocris products. Selected citations for Eggmanone include:
Kan et al (2018) Gli1-labeled adult mesenchymal stem/progenitor cells and hedgehog signaling contribute to endochondral heterotopic ossification. Bone 109 71 PMID: 28645539
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