Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 = 72 nM). Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11. Displays no significant activity on a panel of 442 kinases, 158 GPCRs and 21 phosphatases. Suppresses hedgehog signaling through PDE antagonism, downstream of smoothened signaling. Reduces transcription of Gli1 and Ptc1.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 416.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||12 mL||60.01 mL||120.02 mL|
|1 mM||2.4 mL||12 mL||24 mL|
|2 mM||1.2 mL||6 mL||12 mL|
|10 mM||0.24 mL||1.2 mL||2.4 mL|
References are publications that support the biological activity of the product.
Williams et al (2015) An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell Rep. 11 43 PMID: 25818300
If you know of a relevant reference for Eggmanone, please let us know.
View Related Products by Product Action
Keywords: Eggmanone, Eggmanone supplier, Potent, selective, phosphodiesterases, PDE, 4, inhibitors, inhibits, hedgehog, signallling, Phosphodiesterases, Hedgehog, Signaling, 5695, Tocris Bioscience
Citations for Eggmanone
Citations are publications that use Tocris products.
Currently there are no citations for Eggmanone. Do you know of a great paper that uses Eggmanone from Tocris? Please let us know.
Reviews for Eggmanone
There are currently no reviews for this product. Be the first to review Eggmanone and earn rewards!
Have you used Eggmanone?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.