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Cat.No. 0786 - Edaravone | C10H10N2O | CAS No. 89-25-8
Description: Anti-ischemic and antioxidant
Alternative Names: MCI-186
Chemical Name: 3-Methyl-1-phenyl-2-pyrazolin-5-one
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

A radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.

Technical Data

M. Wt 174.2
Formula C10H10N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 89-25-8
PubChem ID 4021
Smiles CC1=NN(C(=O)C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.42 100

Preparing Stock Solutions

The following data is based on the product molecular weight 174.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.74 mL 28.7 mL 57.41 mL
5 mM 1.15 mL 5.74 mL 11.48 mL
10 mM 0.57 mL 2.87 mL 5.74 mL
50 mM 0.11 mL 0.57 mL 1.15 mL

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References are publications that support the products' biological activity.

Kawai et al (1997) Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 281 921 PMID: 9152402

Kawasaki et al (2007) Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 322 274 PMID: 17429058

Watanabe et al (1994) Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 268 1597 PMID: 8138971

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316

If you know of a relevant reference for Edaravone, please let us know.

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Keywords: Edaravone, supplier, Anti-ischemic, antioxidant, free, radical, scavenger, MCI186, MCI-186, Antioxidants, Autophagy, Antioxidants, Tocris Bioscience

2 Citations for Edaravone

Citations are publications that use Tocris products. Selected citations for Edaravone include:

Tsunekawa et al (2013) Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation. Br J Pharmacol 14 4 PMID: 23289926

Walton et al (2012) Adult neurogenesis transiently generates oxidative stress. PLoS One 7 e35264 PMID: 22558133

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