Edaravone

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Cat.No. 0786 - Edaravone | C10H10N2O | CAS No. 89-25-8
Description: Anti-ischemic and antioxidant
Alternative Names: MCI-186
Chemical Name: 3-Methyl-1-phenyl-2-pyrazolin-5-one
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews

Biological Activity for Edaravone

Edaravone is a radical scavenger and antioxidant which is able to protect against the effects of ischemia, probably by inhibiting the lipoxygenase system. Protects against MPTP-induced neurotoxicity. Inhibits autophagy.

Technical Data for Edaravone

M. Wt 174.2
Formula C10H10N2O
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 89-25-8
PubChem ID 4021
InChI Key QELUYTUMUWHWMC-UHFFFAOYSA-N
Smiles CC1=NN(C(=O)C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Edaravone

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.42 100

Preparing Stock Solutions for Edaravone

The following data is based on the product molecular weight 174.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.74 mL 28.7 mL 57.41 mL
5 mM 1.15 mL 5.74 mL 11.48 mL
10 mM 0.57 mL 2.87 mL 5.74 mL
50 mM 0.11 mL 0.57 mL 1.15 mL

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References for Edaravone

References are publications that support the biological activity of the product.

Kawai et al (1997) Effects of a novel free radical scavenger, MC-186, on ischemic brain damage in rat distal middle cerebral artery occlusion model. J.Pharmacol.Exp.Ther. 281 921 PMID: 9152402

Kawasaki et al (2007) Edaravone (3methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum. J.Pharmacol.Exp.Ther. 322 274 PMID: 17429058

Watanabe et al (1994) Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J.Pharmacol.Exp.Ther. 268 1597 PMID: 8138971

Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316


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Keywords: Edaravone, Edaravone supplier, Anti-ischemic, antioxidant, free, radical, scavenger, MCI186, MCI-186, Antioxidants, Autophagy, 0786, Tocris Bioscience

3 Citations for Edaravone

Citations are publications that use Tocris products. Selected citations for Edaravone include:

Wu et al (2019) Phorbol ester-induced angiogenesis of endothelial progenitor cells: The role of NADPH oxidase-mediated, redox-related matrix metalloproteinase pathways. PLoS One 14 e0209426 PMID: 30645596

Tsunekawa et al (2013) Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation. Br J Pharmacol 14 4 PMID: 23289926

Walton et al (2012) Adult neurogenesis transiently generates oxidative stress. PLoS One 7 e35264 PMID: 22558133


Do you know of a great paper that uses Edaravone from Tocris? Please let us know.

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