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Biological Activity for Echinomycin
Echinomycin is a highly potent and selective HIF-1α inhibitor (IC50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF-κB. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs.
Technical Data for Echinomycin
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Echinomycin
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Echinomycin
The following data is based on the product molecular weight 1101.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||18.16 mL||90.81 mL||181.61 mL|
|0.25 mM||3.63 mL||18.16 mL||36.32 mL|
|0.5 mM||1.82 mL||9.08 mL||18.16 mL|
|2.5 mM||0.36 mL||1.82 mL||3.63 mL|
References for Echinomycin
References are publications that support the biological activity of the product.
Wang et al (2011) Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell 8 399 PMID: 21474104
Kwon et al (2011) Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression. J.Cell.Biochem. 112 3582 PMID: 21793044
Kong et al (2005) Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 65 9047 PMID: 16204079
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1 Citation for Echinomycin
Citations are publications that use Tocris products. Selected citations for Echinomycin include:
David H et al (2020) Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit. Neuron 106 607-623.e5 PMID: 32183943
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Literature in this Area
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