EBPC

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Cat.No. 0518 - EBPC | C14H15NO4 | CAS No. 4450-98-0
Description: Aldose reductase inhibitor
Chemical Name: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent aldose reductase inhibitor. Improves the cytotoxicity of anticancer reagents such as cisplatin (Cat.No. 2251) and doxorubicin (Cat.No. 2252) in HeLa cervical carcinoma cells through an increase in ERK activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 261.28
Formula C14H15NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 4450-98-0
PubChem ID 54677973
InChI Key IGYRPDIWSYGHMY-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C(O)C(=O)N(CC2=CC=CC=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO and to 50 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 261.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.83 mL 19.14 mL 38.27 mL
5 mM 0.77 mL 3.83 mL 7.65 mL
10 mM 0.38 mL 1.91 mL 3.83 mL
50 mM 0.08 mL 0.38 mL 0.77 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Kyoung et al (2002) Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anti-cancer Drugs 13 859 PMID: 12394272

Mylari et al (1991) A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate and its congeners. J.Med.Chem. 34 1011 PMID: 1900532


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Keywords: EBPC, supplier, Aldose, reductase, inhibitors, inhibits, Reductases, Carbohydrate, Metabolism, Pfizer, Aldose, Reductase, Tocris Bioscience

2 Citations for EBPC

Citations are publications that use Tocris products. Selected citations for EBPC include:

Seo et al (2014) Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs. Pharmacol Res Perspect 90 99 PMID: 24695626

Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98 PMID: 22654757


Do you know of a great paper that uses EBPC from Tocris? If so please let us know.

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Literature in this Area

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New Product Guide (Spring/Summer 2017)

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