EBPC

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Cat.No. 0518 - EBPC | C14H15NO4 | CAS No. 4450-98-0
Description: Aldose reductase inhibitor
Chemical Name: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature (1)

Biological Activity

Potent aldose reductase inhibitor. Improves the cytotoxicity of anticancer reagents such as cisplatin (Cat.No. 2251) and doxorubicin (Cat.No. 2252) in HeLa cervical carcinoma cells through an increase in ERK activity.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 261.28
Formula C14H15NO4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 4450-98-0
PubChem ID 54677973
InChI Key IGYRPDIWSYGHMY-UHFFFAOYSA-N
Smiles CCOC(=O)C1=C(O)C(=O)N(CC2=CC=CC=C2)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO and to 50 mM in ethanol

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Kyoung et al (2002) Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anti-cancer Drugs 13 859 PMID: 12394272

Mylari et al (1991) A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate and its congeners. J.Med.Chem. 34 1011 PMID: 1900532


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Keywords: EBPC, EBPC supplier, Aldose, reductase, inhibitors, inhibits, Reductases, Carbohydrate, Metabolism, Pfizer, Reductase, 0518, Tocris Bioscience

2 Citations for EBPC

Citations are publications that use Tocris products. Selected citations for EBPC include:

Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98 PMID: 22654757

Seo et al (2014) Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs. Pharmacol Res Perspect 90 99 PMID: 24695626


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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