Potent aldose reductase inhibitor. Improves the cytotoxicity of anticancer reagents such as cisplatin (Cat.No. 2251) and doxorubicin (Cat.No. 2252) in HeLa cervical carcinoma cells through an increase in ERK activity.
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 100 mM in DMSO and to 50 mM in ethanol|
References are publications that support the biological activity of the product.
Kyoung et al (2002) Inhibition of aldose reductase enhances HeLa cell sensitivity to chemotherapeutic drugs and involves activation of extracellular signal-regulated kinases. Anti-cancer Drugs 13 859 PMID: 12394272
Mylari et al (1991) A highly specific aldose reductase inhibitor, ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate and its congeners. J.Med.Chem. 34 1011 PMID: 1900532
If you know of a relevant reference for EBPC, please let us know.
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Keywords: EBPC, EBPC supplier, Aldose, reductase, inhibitors, inhibits, Reductases, Carbohydrate, Metabolism, Pfizer, Reductase, 0518, Tocris Bioscience
2 Citations for EBPC
Citations are publications that use Tocris products. Selected citations for EBPC include:
Seo et al (2014) Comprehensive analysis of prostaglandin metabolic enzyme expression during pregnancy and the characterization of AKR1B1 as a prostaglandin F synthase at the maternal-conceptus interface in pigs. Pharmacol Res Perspect 90 99 PMID: 24695626
Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98 PMID: 22654757
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