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Cat.No. 2266 - DY131 | C18H21N3O2 | CAS No. 95167-41-2
Description: Agonist selective for estrogen-related receptors ERRβ and ERRγ
Chemical Name: N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine
Purity: ≥99% (HPLC)
Citations (9)
Literature (2)
Pathways (1)

Biological Activity

Novel selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.

Compound Libraries

DY131 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 311.38
Formula C18H21N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 95167-41-2
PubChem ID 5497124
Smiles CCN(CC)C1=CC=C(C=C1)\C=N\NC(=O)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 3.11 10
DMSO 31.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 311.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.21 mL 16.06 mL 32.12 mL
5 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.32 mL 1.61 mL 3.21 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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References are publications that support the biological activity of the product.

Yu and Forman (2005) Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg.Med.Chem.Lett. 15 1311 PMID: 15713377

If you know of a relevant reference for DY131, please let us know.

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View all Estrogen and Related Receptor Agonists

Keywords: DY131, DY131 supplier, agonists, selective, estrogen-related, receptors, ERRβ, ERRbeta, ERRγ, ERRgamma, Estrogen, Receptors, ERRg, ERRb, and, Related, 2266, Tocris Bioscience

9 Citations for DY131

Citations are publications that use Tocris products. Selected citations for DY131 include:

Byerly et al (2013) Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression. Eur J Neurosci 37 1033 PMID: 23360481

Byerly et al (2013) Estrogen-related receptor β deficiency alters body composition and response to restraint stress. BMC Physiol 13 10 PMID: 24053666

Kang et al (2018) Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun 9 1920 PMID: 29765046

Lu et al (2015) Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells. Neuropharmacology 16 21 PMID: 26627478

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for DY131


Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.