Novel selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 311.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.21 mL||16.06 mL||32.12 mL|
|5 mM||0.64 mL||3.21 mL||6.42 mL|
|10 mM||0.32 mL||1.61 mL||3.21 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References are publications that support the products' biological activity.
Yu and Forman (2005) Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg.Med.Chem.Lett. 15 1311 PMID: 15713377
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Keywords: DY131, supplier, agonists, selective, estrogen-related, receptors, ERRβ, ERRbeta, ERRγ, ERRgamma, Estrogen, Receptors, ERRg, ERRb, Estrogen, and, Related, Receptors, Estrogen, and, Related, Receptors, Tocris Bioscience
4 Citations for DY131
Citations are publications that use Tocris products. Selected citations for DY131 include:
Byerly et al (2013) Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression. Eur J Neurosci 37 1033 PMID: 23360481
Byerly et al (2013) Estrogen-related receptor β deficiency alters body composition and response to restraint stress. BMC Physiol 13 10 PMID: 24053666
Gandhari et al (2010) Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells. Mol Cell Endocrinol 315 314 PMID: 19822186
Lu et al (2015) Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells. Neuropharmacology 16 21 PMID: 26627478
Do you know of a great paper that uses DY131 from Tocris? If so please let us know.
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