DY131

Pricing Availability   Qty
Cat.No. 2266 - DY131 | C18H21N3O2 | CAS No. 95167-41-2
Description: Agonist selective for estrogen-related receptors ERRβ and ERRγ
Chemical Name: N-(4-(Diethylaminobenzylidenyl)-N'-(4-hydroxybenzoyl)-hydrazine
Purity: ≥99% (HPLC)
Datasheet
Citations (9)
Reviews
Literature
Pathways

Biological Activity

Novel selective agonist at estrogen-related receptors ERRβ and ERRγ. Displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM.

Compound Libraries

DY131 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 311.38
Formula C18H21N3O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 95167-41-2
PubChem ID 5497124
InChI Key WLKOCYWYAWBGKY-CPNJWEJPSA-N
Smiles CCN(CC)C1=CC=C(C=C1)\C=N\NC(=O)C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 3.11 10
DMSO 31.14 100

Preparing Stock Solutions

The following data is based on the product molecular weight 311.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.21 mL 16.06 mL 32.12 mL
5 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.32 mL 1.61 mL 3.21 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Yu and Forman (2005) Identification of an agonist ligand for estrogen-related receptors ERRβ/γ. Bioorg.Med.Chem.Lett. 15 1311 PMID: 15713377


If you know of a relevant reference for DY131, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Estrogen and Related Receptor Agonists

Keywords: DY131, DY131 supplier, agonists, selective, estrogen-related, receptors, ERRβ, ERRbeta, ERRγ, ERRgamma, Estrogen, Receptors, ERRg, ERRb, and, Related, 2266, Tocris Bioscience

9 Citations for DY131

Citations are publications that use Tocris products. Selected citations for DY131 include:

Kang et al (2018) Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun 9 1920 PMID: 29765046

Heckler et al (2016) Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer. Oncotarget 7 47201 PMID: 27363015

Lu et al (2015) Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells. Neuropharmacology 16 21 PMID: 26627478

Heckler and Riggins (2014) ERRβ splice variants differentially regulate cell cycle progression. Cell Cycle 14 31 PMID: 25496115

Luo et al (2014) Estrogen-related receptor γ serves a role in blood pressure homeostasis during pregnancy. Mol Endocrinol 28 965 PMID: 24725083

Gandhari et al (2010) Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells. Mol Cell Endocrinol 315 314 PMID: 19822186

Huang (2018) DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice. Invest Ophthalmol Vis Sci 59 2623 PMID: 29847669

Byerly et al (2013) Estrogen-related receptor β deletion modulates whole-body energy balance via estrogen-related receptor γ and attenuates neuropeptide Y gene expression. Eur J Neurosci 37 1033 PMID: 23360481

Byerly et al (2013) Estrogen-related receptor β deficiency alters body composition and response to restraint stress. BMC Physiol 13 10 PMID: 24053666


Do you know of a great paper that uses DY131 from Tocris? Please let us know.

Reviews for DY131

There are currently no reviews for this product. Be the first to review DY131 and earn rewards!

Have you used DY131?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for DY131

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.