DY 268

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Description: Potent FXR antagonist
Chemical Name: 1-[(3-Methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide
Purity: ≥98% (HPLC)

Biological Activity for DY 268

DY 268 is a potent FXR antagonist (IC50 = 7.5 nM). Exhibits no detectable cytotoxicity in cell-based assays.

Licensing Information

Sold under license from the Beckman Research Institute of the City of Hope.

Technical Data for DY 268

M. Wt 560.66
Formula C30H32N4O5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1609564-75-1
PubChem ID 90656831
Smiles CC1=C(S(N2CCOCC2)(=O)=O)C=C(NC(C3=CN(CC4=CC(OC)=CC=C4)N=C3C5=CC=C(C)C=C5)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DY 268

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 56.07 100

Preparing Stock Solutions for DY 268

The following data is based on the product molecular weight 560.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References for DY 268

References are publications that support the biological activity of the product.

Yu et al (2014) Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg.Med.Chem. 22 2919 PMID: 24775917

If you know of a relevant reference for DY 268, please let us know.

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Citations for DY 268

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