DY 268

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Cat.No. 5656 - DY 268 | C30H32N4O5S | CAS No. 1609564-75-1
Description: Potent FXR antagonist
Chemical Name: 1-[(3-Methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent FXR antagonist (IC50 = 7.5 nM). Exhibits no detectable cytotoxicity in cell-based assays.

Licensing Information

Sold under license from the Beckman Research Institute of the City of Hope.

Technical Data

M. Wt 560.66
Formula C30H32N4O5S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1609564-75-1
PubChem ID 90656831
InChI Key KQSPAAPFKIEUGH-UHFFFAOYSA-N
Smiles CC1=C(S(N2CCOCC2)(=O)=O)C=C(NC(C3=CN(CC4=CC(OC)=CC=C4)N=C3C5=CC=C(C)C=C5)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 56.07 100

Preparing Stock Solutions

The following data is based on the product molecular weight 560.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.92 mL 17.84 mL
5 mM 0.36 mL 1.78 mL 3.57 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Yu et al (2014) Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg.Med.Chem. 22 2919 PMID: 24775917


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Keywords: DY268 farnesoid X receptors antagonists antagonism FXR nuclear potent LXR-like Receptors

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