Displays high and roughly equal affinity for both σ1 and σ2 receptors.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 239.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.18 mL||20.89 mL||41.79 mL|
|5 mM||0.84 mL||4.18 mL||8.36 mL|
|10 mM||0.42 mL||2.09 mL||4.18 mL|
|50 mM||0.08 mL||0.42 mL||0.84 mL|
References are publications that support the products' biological activity.
He et al (1993) Synthesis and binding characteristics of potential SPECT imaging agents for σ1 and σ2 binding sites. J.Med.Chem. 36 566 PMID: 8496936
Quirion et al (1992) A proposal for the classification of sigma binding sites. TiPS 13 85 PMID: 1315463
If you know of a relevant reference for DTG, please let us know.
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Keywords: DTG, supplier, High, affinity, ligand, σ1, sigma1, σ2, sigma2, General, Receptors, Sigma-Related, Sigma-Related, Tocris Bioscience
2 Citations for DTG
Citations are publications that use Tocris products. Selected citations for DTG include:
Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Neuroscience 350 290 PMID: 24891452
Hall et al (2009) Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. PLoS One 164 470 PMID: 19723565
Do you know of a great paper that uses DTG from Tocris? If so please let us know.
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New Product Guide (Spring/Summer 2017)
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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