DTG

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Cat.No. 0841 - DTG | C15H17N3 | CAS No. 97-39-2
Description: High affinity ligand (σ1 = σ2)
Chemical Name: 1,3-Di-(2-tolyl)guanidine
Datasheet
Citations (2)
Reviews (1)
Literature (1)

Biological Activity

Displays high and roughly equal affinity for both σ1 and σ2 receptors.

Technical Data

M. Wt 239.32
Formula C15H17N3
Storage Store at RT
CAS Number 97-39-2
PubChem ID 7333
InChI Key OPNUROKCUBTKLF-UHFFFAOYSA-N
Smiles CC1=C(NC(=N)NC2=C(C)C=CC=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 5.98 25
DMSO 5.98 25

Preparing Stock Solutions

The following data is based on the product molecular weight 239.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 16.71 mL 83.57 mL 167.14 mL
1.25 mM 3.34 mL 16.71 mL 33.43 mL
2.5 mM 1.67 mL 8.36 mL 16.71 mL
12.5 mM 0.33 mL 1.67 mL 3.34 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

He et al (1993) Synthesis and binding characteristics of potential SPECT imaging agents for σ1 and σ2 binding sites. J.Med.Chem. 36 566 PMID: 8496936

Quirion et al (1992) A proposal for the classification of sigma binding sites. TiPS 13 85 PMID: 1315463


If you know of a relevant reference for DTG, please let us know.

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Keywords: DTG, DTG supplier, High, affinity, ligand, σ1, sigma1, σ2, sigma2, General, Receptors, Sigma-Related, 0841, Tocris Bioscience

2 Citations for DTG

Citations are publications that use Tocris products. Selected citations for DTG include:

Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Neuroscience 350 290 PMID: 24891452

Hall et al (2009) Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. PLoS One 164 470 PMID: 19723565


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Reviews for DTG

Average Rating: 5 (Based on 1 Review.)

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DTG specifically protects sigma-1 and sigma-2 receptors binding sites..
By Timur Mavlyutov on 01/06/2018
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: PC12

Photolabeling experiment by Iodoazidofenpropimorph labels multiple receptors, which can be later seen on auto radiogram. Sigma-1 (26kDa) and Sigma-2 (18kDa) receptors were also labeled. To be sure that these two bands are true Sigma-1 and Sigma-2 receptors, photolabeling experiment was performed in the presence of DTG (second lane). Both Sigma-1 and Sigma-2 receptors were selectively protected.

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Literature in this Area

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