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Cat.No. 0841 - DTG | C15H17N3 | CAS No. 97-39-2
Description: High affinity ligand (σ1 = σ2)
Chemical Name: 1,3-Di-(2-tolyl)guanidine
Citations (2)
Reviews (1)

Biological Activity

Displays high and roughly equal affinity for both σ1 and σ2 receptors.

Technical Data

M. Wt 239.32
Formula C15H17N3
Storage Store at RT
CAS Number 97-39-2
PubChem ID 7333
Smiles CC1=C(NC(=N)NC2=C(C)C=CC=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 5.98 25
ethanol 5.98 25

Preparing Stock Solutions

The following data is based on the product molecular weight 239.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.18 mL 20.89 mL 41.79 mL
5 mM 0.84 mL 4.18 mL 8.36 mL
10 mM 0.42 mL 2.09 mL 4.18 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

He et al (1993) Synthesis and binding characteristics of potential SPECT imaging agents for σ1 and σ2 binding sites. J.Med.Chem. 36 566 PMID: 8496936

Quirion et al (1992) A proposal for the classification of sigma binding sites. TiPS 13 85 PMID: 1315463

If you know of a relevant reference for DTG, please let us know.

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Keywords: DTG, supplier, High, affinity, ligand, σ1, sigma1, σ2, sigma2, General, Receptors, Sigma-Related, Sigma-Related, Tocris Bioscience

2 Citations for DTG

Citations are publications that use Tocris products. Selected citations for DTG include:

Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Neuroscience 350 290 PMID: 24891452

Hall et al (2009) Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. PLoS One 164 470 PMID: 19723565

Do you know of a great paper that uses DTG from Tocris? If so please let us know.

Reviews for DTG

Average Rating: 5 (Based on 1 Review)

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DTG specifically protects sigma-1 and sigma-2 receptors binding sites.
By Timur Mavlyutov on 01/06/2018
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: PC12

Photolabeling experiment by Iodoazidofenpropimorph labels multiple receptors, which can be later seen on auto radiogram. Sigma-1 (26kDa) and Sigma-2 (18kDa) receptors were also labeled. To be sure that these two bands are true Sigma-1 and Sigma-2 receptors, photolabeling experiment was performed in the presence of DTG (second lane). Both Sigma-1 and Sigma-2 receptors were selectively protected.

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