DTG

Pricing Availability Delivery Time Qty
Cat.No. 0841 - DTG | C15H17N3 | CAS No. 97-39-2
Description: High affinity ligand (σ1 = σ2)
Chemical Name: 1,3-Di-(2-tolyl)guanidine
Datasheet
Citations (2)
Literature

Biological Activity

Displays high and roughly equal affinity for both σ1 and σ2 receptors.

Technical Data

M. Wt 239.32
Formula C15H17N3
Storage Store at RT
CAS Number 97-39-2
PubChem ID 7333
InChI Key OPNUROKCUBTKLF-UHFFFAOYSA-N
Smiles CC1=C(NC(=N)NC2=C(C)C=CC=C2)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.98 25
ethanol 5.98 25

Preparing Stock Solutions

The following data is based on the product molecular weight 239.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.18 mL 20.89 mL 41.79 mL
5 mM 0.84 mL 4.18 mL 8.36 mL
10 mM 0.42 mL 2.09 mL 4.18 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

He et al (1993) Synthesis and binding characteristics of potential SPECT imaging agents for σ1 and σ2 binding sites. J.Med.Chem. 36 566 PMID: 8496936

Quirion et al (1992) A proposal for the classification of sigma binding sites. TiPS 13 85 PMID: 1315463


If you know of a relevant reference for DTG, please let us know.

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View all Sigma-Related Ligands

Keywords: High affinity ligand σ1 sigma1 σ2 sigma2 General Receptors Sigma-Related

2 Citations for DTG

Citations are publications that use Tocris products. Selected citations for DTG include:

Pan et al (2014) σ-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons. Neuroscience 350 290 PMID: 24891452

Hall et al (2009) Delayed treatments for stroke influence neuronal death in rat organotypic slice cultures subjected to oxygen glucose deprivation. PLoS One 164 470 PMID: 19723565


Do you know of a great paper that uses DTG from Tocris? If so please let us know.

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Reviews

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for DTG

Protocols

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