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Biological Activity for dTAG-13-NEG
dTAG-13-NEG is a negative control for dTAG-13 (Cat. No. 6605).
Sold under license from Dana-Farber Cancer Institute
Technical Data for dTAG-13-NEG
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for dTAG-13-NEG
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for dTAG-13-NEG
The following data is based on the product molecular weight 1063.19. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.94 mL||4.7 mL||9.41 mL|
|5 mM||0.19 mL||0.94 mL||1.88 mL|
|10 mM||0.09 mL||0.47 mL||0.94 mL|
|50 mM||0.02 mL||0.09 mL||0.19 mL|
References for dTAG-13-NEG
References are publications that support the biological activity of the product.
Nabet et al (2020) Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nat.Commun. 11 4687 PMID: 32948771
Nabet et al (2018) The dTAG system for immediate and target-specific protein degradation. Nat.Chem.Biol. 13 431 PMID: 29581585
If you know of a relevant reference for dTAG-13-NEG, please let us know.
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Keywords: dTAG-13-NEG, dTAG-13-NEG supplier, dTAG13, degraders, degrades, degradation, FKBP12F36V, fusion, protein, mutant, PROTAC, proteolysis, targeting, chimera, cereblon, negative, controls, TAG, Degradation, Platform, 6916, Tocris Bioscience
Citations for dTAG-13-NEG
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Currently there are no citations for dTAG-13-NEG. Do you know of a great paper that uses dTAG-13-NEG from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Targeted Protein Degradation Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Custom Degrader Services
- Ubiquitin-Proteasome System Proteins and Assays
- Assays for Protein Degradation
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia