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Description: Potent and selective N-SMase2 inhibitor; brain penetrant
Chemical Name: 2,6-Dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol
Purity: ≥98% (HPLC)

Biological Activity for DPTIP

DPTIP is a potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.

Technical Data for DPTIP

M. Wt 378.45
Formula C21H18N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 351353-48-5
PubChem ID 1131802
Smiles COC1=CC(C2=NC(C3=CC=CC=C3)=C(C4=CC=CS4)N2)=CC(OC)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DPTIP

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.84 100

Preparing Stock Solutions for DPTIP

The following data is based on the product molecular weight 378.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.42 mL
5 mM 0.53 mL 2.64 mL 5.28 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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References for DPTIP

References are publications that support the biological activity of the product.

Rojas et al (2018) DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci.Rep. 8 17715 PMID: 30531925

If you know of a relevant reference for DPTIP, please let us know.

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