DPTIP

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Cat.No. 6903 - DPTIP | C21H18N2O3S | CAS No. 351353-48-5
Description: Potent and selective N-SMase2 inhibitor; brain penetrant
Chemical Name: 2,6-Dimethoxy-4-[4-phenyl-5-(2-thienyl)-1H-imidazol-2-yl]phenol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Potent and selective sphingomyelin phosphodiesterase (N-SMase2) inhibitor (IC50 = 30 nM). Exhibits no inhibition of related enzymes alkaline phosphatase, phosphomonoesterase or acid sphingomyelinase. Inhibits extracellular vesicle (EV) release in primary astrocyte cultures and in vivo. Attenuates IL-1β-induced astrocyte-derived EV release in a mouse model of brain injury and suppresses infiltration of immune cells into the brain. Metabolically stable and brain penetrant.

Technical Data

M. Wt 378.45
Formula C21H18N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 351353-48-5
PubChem ID 1131802
InChI Key JMXVHYPSBANVAQ-UHFFFAOYSA-N
Smiles COC1=CC(C2=NC(C3=CC=CC=C3)=C(C4=CC=CS4)N2)=CC(OC)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.84 100

Preparing Stock Solutions

The following data is based on the product molecular weight 378.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.42 mL
5 mM 0.53 mL 2.64 mL 5.28 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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References

References are publications that support the biological activity of the product.

Rojas et al (2018) DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. Sci.Rep. 8 17715 PMID: 30531925


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Keywords: DPTIP, DPTIP supplier, neutral, sphingomyelinase, 2, nSMase2, inhibition, inhibitors, inhibits, Sphingomyelin, phosphodiesterase, SMase, metabolically, stable, brain, penetrant, bbb, Other, Hydrolases, 6903, Tocris Bioscience

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