DPPE fumarate

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Cat.No. 0743 - DPPE fumarate | C19H25NO.C4H4O4 | CAS No. 1185241-83-1
Description: Inhibitor of histamine binding at the intracellular binding site
Chemical Name: N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine fumarate
Datasheet
Citations
Literature

Biological Activity

Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor. Induces of sterol accumulation in MCF7 cells. An inhibitor of histamine binding at the intracellular histamine (Hlc) site.

Technical Data

M. Wt 399.49
Formula C19H25NO.C4H4O4
Storage Desiccate at -20°C
CAS Number 1185241-83-1
PubChem ID 45073473
InChI Key ZOOMDYHTGZSGDD-WLHGVMLRSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 399.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service.
Safety Datasheet

References

References are publications that support the products' biological activity.

Brandes et al (1990) Histamine as an intracellular messenger. Biochem.Pharmacol. 40 1677 PMID: 2242003

Brandes and Hermonat (1984) A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver microsomes. Biochem.Biophys.Res.Commun. 123 724 PMID: 6548377

Sturman et al (1994) Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice. Agents Actions 41 C68 PMID: 7976808

Kedjouar et al (2004) Molecular characterization of the microsomal tamoxifen binding site. J.Biol.Chem. 279 34048 PMID: 15175332


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Keywords: DPPE fumarate, supplier, Ligand, antiestrogen, binding, site, inhibitors, inhibits, histamine, intracellular, ER, ERR, Estrogen, Receptors, Histaminergic-, Compounds, Histaminergic-Related, Compounds, Tocris Bioscience

Citations for DPPE fumarate

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Literature in this Area

Histamine Receptors

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.

Pathways for DPPE fumarate

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