DPPE fumarate

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Cat.No. 0743 - DPPE fumarate | C19H25NO.C4H4O4 | CAS No. 1185241-83-1
Description: Inhibitor of histamine binding at the intracellular binding site
Chemical Name: N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine fumarate
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity

Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor. Induces of sterol accumulation in MCF7 cells. An inhibitor of histamine binding at the intracellular histamine (Hlc) site.

Technical Data

M. Wt 399.49
Formula C19H25NO.C4H4O4
Storage Desiccate at -20°C
CAS Number 1185241-83-1
PubChem ID 45073473
InChI Key ZOOMDYHTGZSGDD-WLHGVMLRSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.95 100

Preparing Stock Solutions

The following data is based on the product molecular weight 399.49. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.5 mL 12.52 mL 25.03 mL
5 mM 0.5 mL 2.5 mL 5.01 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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References

References are publications that support the biological activity of the product.

Brandes et al (1990) Histamine as an intracellular messenger. Biochem.Pharmacol. 40 1677 PMID: 2242003

Brandes and Hermonat (1984) A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver microsomes. Biochem.Biophys.Res.Commun. 123 724 PMID: 6548377

Sturman et al (1994) Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice. Agents Actions 41 C68 PMID: 7976808

Kedjouar et al (2004) Molecular characterization of the microsomal tamox. binding site. J.Biol.Chem. 279 34048 PMID: 15175332


If you know of a relevant reference for DPPE fumarate, please let us know.

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Keywords: DPPE fumarate, DPPE fumarate supplier, Ligand, antiestrogen, binding, site, inhibitors, inhibits, histamine, intracellular, ER, ERR, Estrogen, Receptors, Histaminergic-, Compounds, Histaminergic-Related, and, Related, 0743, Tocris Bioscience

1 Citation for DPPE fumarate

Citations are publications that use Tocris products. Selected citations for DPPE fumarate include:

Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Histamine Receptors

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.