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DPC AJ1951

Cat. No. 5487 Submit a Review Datasheet / COA / SDS
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Cat.No. 5487 - DPC AJ1951 | Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Arg-Ala-Lys-Tyr-NH2 | CAS No. 943519-33-3
Description: Potent parathyroid hormone (PTH) receptor agonist
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent 14 amino acid peptide agonist of the parathyroid hormone (PTH) receptor (EC50 = 26 nM).

Technical Data

M. Wt 1666.98
Formula C76H127N23O19
Sequence XVXEIQLXHQRAKY

(Modifications: X-1, X-3 = Aib, X-8 = Nle, Tyr-14 = C-terminal amide)
Storage Store at -20°C
CAS Number 943519-33-3
PubChem ID 44584922
InChI Key PNJXWIJKATVXEY-FAQCDESUSA-N
Smiles [H]N([C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O)C(=O)C(C)(C)NC(=O)[C@@H](N([H])C(=O)C(C)(C)N)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

Carter et al (2007) Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe. Proc.Natl.Acad.Sci.U.S.A. 104 6846 PMID: 17428923

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