DPC AJ1951

Pricing Availability Delivery Time Qty
Cat.No. 5487 - DPC AJ1951 | Aib-Val-Aib-Glu-Ile-Gln-Leu-Nle-His-Gln-Arg-Ala-Lys-Tyr-NH2 | CAS No. 943519-33-3
Description: Potent parathyroid hormone (PTH) receptor agonist
Datasheet
Citations
Literature

Biological Activity

Potent 14 amino acid peptide agonist of the parathyroid hormone (PTH) receptor (EC50 = 26 nM).

Technical Data

M. Wt 1666.98
Formula C76H127N23O19
Sequence XVXEIQLXHQRAKY

(Modifications: X-1, X-3 = Aib, X-8 = Nle, Tyr-14 = C-terminal amide)

Storage Store at -20°C
CAS Number 943519-33-3
PubChem ID 44584922
InChI Key PNJXWIJKATVXEY-FAQCDESUSA-N
Smiles [H]N([C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O)C(=O)C(C)(C)NC(=O)[C@@H](N([H])C(=O)C(C)(C)N)C(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1666.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.6 mL 3 mL 6 mL
5 mM 0.12 mL 0.6 mL 1.2 mL
10 mM 0.06 mL 0.3 mL 0.6 mL
50 mM 0.01 mL 0.06 mL 0.12 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Carter et al (2007) Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe. Proc.Natl.Acad.Sci.U.S.A. 104 6846 PMID: 17428923


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