Dooku 1

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Cat.No. 6568 - Dooku 1 | C13H9Cl2N3OS
Description: Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity
Chemical Name: 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Reversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ~1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonize Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.

Technical Data

M. Wt 326.2
Formula C13H9Cl2N3OS
Storage Store at +4°C
Purity ≥98% (HPLC)
Smiles ClC1=C(CSC2=NN=C(O2)C3=CC=CN3)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 326.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.33 mL 30.66 mL
5 mM 0.61 mL 3.07 mL 6.13 mL
10 mM 0.31 mL 1.53 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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References

References are publications that support the biological activity of the product.

Evans et al (2018) Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br.J.Pharmacol. 175 1744 PMID: 29498036


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