Dooku 1

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Description: Reversibly blocks Yoda1 activity; does not affect constitutive Piezo1 activity
Chemical Name: 2-[(2,6-Dichlorobenzyl)thio)-5-(1H-pyrrol-2-yl)-1,3,4-oxadiazole
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews

Biological Activity for Dooku 1

Dooku 1 reversibly blocks Yoda1 (Cat. No. 5586) activity (IC50 = ~1.5 μM). Exhibits no effect on constitutive Piezo1 channel activity, but antagonizes Yoda1-induced Piezo1 activation in endothelial cells, and inhibits Yoda1-induced Ca2+-entry in vitro. Also blocks Yoda1-induced relaxation of aorta ex vivo.

Technical Data for Dooku 1

M. Wt 326.2
Formula C13H9Cl2N3OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 2253744-54-4
PubChem ID 137321150
InChI Key MNPOBXLPCWFONX-UHFFFAOYSA-N
Smiles ClC1=C(CSC2=NN=C(O2)C3=CC=CN3)C(Cl)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Dooku 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 32.62 100

Preparing Stock Solutions for Dooku 1

The following data is based on the product molecular weight 326.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.07 mL 15.33 mL 30.66 mL
5 mM 0.61 mL 3.07 mL 6.13 mL
10 mM 0.31 mL 1.53 mL 3.07 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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Product Datasheets for Dooku 1

Certificate of Analysis / Product Datasheet
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References for Dooku 1

References are publications that support the biological activity of the product.

Evans et al (2018) Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br.J.Pharmacol. 175 1744 PMID: 29498036


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1 Citation for Dooku 1

Citations are publications that use Tocris products. Selected citations for Dooku 1 include:

Yan et al (2022) Mechanosensitive piezo1 calcium channel activates connexin 43 hemichannels through PI3K signaling pathway in bone. Cell Biosci 12 191 PMID: 36457052


Do you know of a great paper that uses Dooku 1 from Tocris? Please let us know.

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