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Peripheral dopamine D2-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 425.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.35 mL||11.74 mL||23.48 mL|
|5 mM||0.47 mL||2.35 mL||4.7 mL|
|10 mM||0.23 mL||1.17 mL||2.35 mL|
|50 mM||0.05 mL||0.23 mL||0.47 mL|
References are publications that support the biological activity of the product.
Neimegeers et al (1980) The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch.Int.Pharmacodyn.Ther. 244 130 PMID: 7416883
Prakash and Wagstaff (1998) Domperidone. A review of its use in diabetic gastropathy. Drugs 56 429 PMID: 9777316
Osinski et al (2005) DA D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol.Biochem.Behav. 81 211 PMID: 15894081
If you know of a relevant reference for Domperidone, please let us know.
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Keywords: Domperidone, Domperidone supplier, Peripheral, D2-like, antagonists, Dopamine, Non-Selective, Receptors, dopaminergic, R33812, R, 33812, Non-selective, 2536, Tocris Bioscience
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.