Domperidone

Discontinued Product

Domperidone (Cat. No. 2536) has been withdrawn from sale for commercial reasons.
Description: Peripheral D2-like antagonist
Alternative Names: R 33812
Chemical Name: 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity for Domperidone

Domperidone is a peripheral dopamine D2-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).

Technical Data for Domperidone

M. Wt 425.92
Formula C22H24ClN5O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 57808-66-9
PubChem ID 3151
InChI Key FGXWKSZFVQUSTL-UHFFFAOYSA-N
Smiles ClC1=CC=C2N(C3CCN(CCCN4C(=O)NC5=C4C=CC=C5)CC3)C(=O)NC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Domperidone

References are publications that support the biological activity of the product.

Neimegeers et al (1980) The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch.Int.Pharmacodyn.Ther. 244 130 PMID: 7416883

Prakash and Wagstaff (1998) Domperidone. A review of its use in diabetic gastropathy. Drugs 56 429 PMID: 9777316

Osinski et al (2005) DA D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol.Biochem.Behav. 81 211 PMID: 15894081

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Keywords: Domperidone, Domperidone supplier, Peripheral, D2-like, antagonists, Dopamine, Non-Selective, Receptors, dopaminergic, R33812, R, 33812, Non-selective, 2536, Tocris Bioscience

Citations for Domperidone

Citations are publications that use Tocris products.

Currently there are no citations for Domperidone.

Reviews for Domperidone

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Dopamine Receptors Scientific Review

Dopamine Receptors Scientific Review

Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.