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Cat.No. 2536 - Domperidone | C22H24ClN5O2 | CAS No. 57808-66-9
Description: Peripheral D2-like antagonist
Alternative Names: R 33812
Chemical Name: 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥99% (HPLC)
Literature (5)

Biological Activity for Domperidone

Domperidone is a peripheral dopamine D2-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).

Technical Data for Domperidone

M. Wt 425.92
Formula C22H24ClN5O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 57808-66-9
PubChem ID 3151
Smiles ClC1=CC=C2N(C3CCN(CCCN4C(=O)NC5=C4C=CC=C5)CC3)C(=O)NC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Domperidone

Solvent Max Conc. mg/mL Max Conc. mM
1eq. HCl 2.13 5
DMSO 42.59 100

Preparing Stock Solutions for Domperidone

The following data is based on the product molecular weight 425.92. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.74 mL 23.48 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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References for Domperidone

References are publications that support the biological activity of the product.

Neimegeers et al (1980) The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch.Int.Pharmacodyn.Ther. 244 130 PMID: 7416883

Prakash and Wagstaff (1998) Domperidone. A review of its use in diabetic gastropathy. Drugs 56 429 PMID: 9777316

Osinski et al (2005) DA D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol.Biochem.Behav. 81 211 PMID: 15894081

If you know of a relevant reference for Domperidone, please let us know.

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Keywords: Domperidone, Domperidone supplier, Peripheral, D2-like, antagonists, Dopamine, Non-Selective, Receptors, dopaminergic, R33812, R, 33812, Non-selective, 2536, Tocris Bioscience

Citations for Domperidone

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