Dolasetron mesylate

Discontinued Product

Dolasetron mesylate (Cat. No. 5629) has been withdrawn from sale for commercial reasons.
Cat.No. 5629 - Dolasetron mesylate | C19H20N2O3.CH3SO3H | CAS No. 115956-13-3
Description: Potent and selective 5-HT3 antagonist
Chemical Name: 3-Oxooctahydro-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)

Biological Activity

Potent and selective 5-HT3 receptor antagonist (pIC50 = 7.55). Exhibits 200-fold selectivity for 5-HT3 over 5-HT1A, 5-HT1B and 5-HT2 receptors, and a range of other GPCRs. Blocks the 5-HT-elicited von Bezold-Jarisch reflex in rats and suppresses cisplatin-induced vomiting in ferrets.

Technical Data

M. Wt 420.48
Formula C19H20N2O3.CH3SO3H
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 115956-13-3
PubChem ID 60653
InChI Key PSGRLCOSIXJUAL-VPUTYDRXSA-N
Smiles O=C(O[C@@H]3C[C@H](C5)N(CC(C5C4)=O)[C@@]4([H])C3)C2=CNC1=CC=CC=C12.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Miller (1993) Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptors. Drug Dev. Res. 28 87

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Keywords: Dolasetron mesylate, Dolasetron mesylate supplier, 5-HT3, antagonists, GPCRs, vomiting, potent, selective, antagonism, antiemetic, serotonin, Receptors, 5629, Tocris Bioscience

Citations for Dolasetron mesylate

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Literature in this Area

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Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.