Dolasetron mesylate

Pricing Availability Delivery Time Qty
Cat.No. 5629 - Dolasetron mesylate | C19H20N2O3.CH3SO3H | CAS No. 115956-13-3
Description: Potent and selective 5-HT3 antagonist
Chemical Name: 3-Oxooctahydro-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective 5-HT3 receptor antagonist (pIC50 = 7.55). Exhibits 200-fold selectivity for 5-HT3 over 5-HT1A, 5-HT1B and 5-HT2 receptors, and a range of other GPCRs. Blocks the 5-HT-elicited von Bezold-Jarisch reflex in rats and suppresses cisplatin-induced vomiting in ferrets.

Compound Libraries

Dolasetron mesylate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 420.48
Formula C19H20N2O3.CH3SO3H
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 115956-13-3
PubChem ID 60653
InChI Key PSGRLCOSIXJUAL-VPUTYDRXSA-N
Smiles O=C(O[C@@H]3C[C@H](C5)N(CC(C5C4)=O)[C@@]4([H])C3)C2=CNC1=CC=CC=C12.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.05 100
water 42.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 420.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Miller (1993) Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptors. Drug Dev. Res. 28 87 PMID:


If you know of a relevant reference for Dolasetron mesylate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT3 Receptor Antagonists

Keywords: Dolasetron mesylate, supplier, 5-HT3, antagonists, GPCRs, vomiting, potent, selective, antagonism, antiemetic, serotonin, 5-HT3, Receptors, 5-HT3, Receptors, Tocris Bioscience

Citations for Dolasetron mesylate

Citations are publications that use Tocris products.

Currently there are no citations for Dolasetron mesylate. Do you know of a great paper that uses Dolasetron mesylate from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Pathways for Dolasetron mesylate

Protocols

TODO: Add Protocols