Dolasetron mesylate

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Cat.No. 5629 - Dolasetron mesylate | C19H20N2O3.CH3SO3H | CAS No. 115956-13-3
Description: Potent and selective 5-HT3 antagonist
Chemical Name: 3-Oxooctahydro-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective 5-HT3 receptor antagonist (pIC50 = 7.55). Exhibits 200-fold selectivity for 5-HT3 over 5-HT1A, 5-HT1B and 5-HT2 receptors, and a range of other GPCRs. Blocks the 5-HT-elicited von Bezold-Jarisch reflex in rats and suppresses cisplatin-induced vomiting in ferrets.

Compound Libraries

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Technical Data

M. Wt 420.48
Formula C19H20N2O3.CH3SO3H
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 115956-13-3
PubChem ID 60653
InChI Key PSGRLCOSIXJUAL-VPUTYDRXSA-N
Smiles O=C(O[C@@H]3C[C@H](C5)N(CC(C5C4)=O)[C@@]4([H])C3)C2=CNC1=CC=CC=C12.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.05 100
water 42.05 100

Preparing Stock Solutions

The following data is based on the product molecular weight 420.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References

References are publications that support the biological activity of the product.

Miller (1993) Pharmacological properties of dolasetron, a potent and selective antagonist at 5-HT3 receptors. Drug Dev. Res. 28 87


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Citations for Dolasetron mesylate

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Literature in this Area

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Ion Channel

Ion Channel Product Listing

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5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.