Dobutamine hydrochloride

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Cat.No. 0515 - Dobutamine hydrochloride | C18H23NO3.HCl | CAS No. 49745-95-1
Description: α1, β1 and β2 agonist
Chemical Name: 4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]aminoethyl-1,2-benzenediol hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (4)

Biological Activity

β1- and β2-adrenoceptor agonist with some action at the α1-adrenoceptor.

Compound Libraries

Dobutamine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 337.85
Formula C18H23NO3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 49745-95-1
PubChem ID 65324
InChI Key BQKADKWNRWCIJL-UHFFFAOYSA-N
Smiles Cl.CC(CCC1=CC=C(O)C=C1)NCCC1=CC=C(O)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 337.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.8 mL 29.6 mL
5 mM 0.59 mL 2.96 mL 5.92 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Brown et al (1987) Dobutamine: positive inotropy by nonselective adrenoceptor agonism in isolated guinea pig and human myocardium. Naunyn Schmiedebergs Arch.Pharmacol. 335 385 PMID: 3600817

Deighton et al (1992) Characterization of the beta adrenoceptor subtype(s) mediating the positive inotropic effects of epinine, DA, dobutamine, denopamine and xamoterol in isolated human right atrium. J.Pharmacol.Exp.Ther. 262 532 PMID: 1354251

Merck Index 12 3456


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3 Citations for Dobutamine hydrochloride

Citations are publications that use Tocris products. Selected citations for Dobutamine hydrochloride include:

Skeberdis et al (1997) Pharmacological characterization of the receptors involved in the beta-adrenoceptor-mediated stimulation of the L-type Ca2+ current in frog ventricular myocytes. Br J Pharmacol 121 1277 PMID: 9257904

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Biol Reprod 329 350 PMID: 19144685

Li et al (2017) Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med 23 733 PMID: 28459438


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Literature in this Area

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