Dobutamine hydrochloride

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Cat.No. 0515 - Dobutamine hydrochloride | C18H23NO3.HCl | CAS No. 49745-95-1
Description: α1, β1 and β2 agonist
Chemical Name: 4-[2-[[3-(4-Hydroxyphenyl)-1-methylpropyl]aminoethyl-1,2-benzenediol hydrochloride
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

β1- and β2-adrenoceptor agonist with some action at the α1-adrenoceptor.

Compound Libraries

Dobutamine hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 337.85
Formula C18H23NO3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 49745-95-1
PubChem ID 65324
Smiles Cl.CC(CCC1=CC=C(O)C=C1)NCCC1=CC=C(O)C(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.78 100

Preparing Stock Solutions

The following data is based on the product molecular weight 337.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.8 mL 29.6 mL
5 mM 0.59 mL 2.96 mL 5.92 mL
10 mM 0.3 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.3 mL 0.59 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Brown et al (1987) Dobutamine: positive inotropy by nonselective adrenoceptor agonism in isolated guinea pig and human myocardium. Naunyn Schmiedebergs Arch.Pharmacol. 335 385 PMID: 3600817

Deighton et al (1992) Characterization of the beta adrenoceptor subtype(s) mediating the positive inotropic effects of epinine, dopamine, dobutamine, denopamine and xamoterol in isolated human right atrium. J.Pharmacol.Exp.Ther. 262 532 PMID: 1354251

Merck Index 12 3456 PMID:

If you know of a relevant reference for Dobutamine hydrochloride, please let us know.

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2 Citations for Dobutamine hydrochloride

Citations are publications that use Tocris products. Selected citations for Dobutamine hydrochloride include:

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Biol Reprod 329 350 PMID: 19144685

Skeberdis et al (1997) Pharmacological characterization of the receptors involved in the beta-adrenoceptor-mediated stimulation of the L-type Ca2+ current in frog ventricular myocytes. Br J Pharmacol 121 1277 PMID: 9257904

Do you know of a great paper that uses Dobutamine hydrochloride from Tocris? If so please let us know.

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