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β1- and β2-adrenoceptor agonist with some action at the α1-adrenoceptor.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 337.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.96 mL||14.8 mL||29.6 mL|
|5 mM||0.59 mL||2.96 mL||5.92 mL|
|10 mM||0.3 mL||1.48 mL||2.96 mL|
|50 mM||0.06 mL||0.3 mL||0.59 mL|
References are publications that support the biological activity of the product.
Brown et al (1987) Dobutamine: positive inotropy by nonselective adrenoceptor agonism in isolated guinea pig and human myocardium. Naunyn Schmiedebergs Arch.Pharmacol. 335 385 PMID: 3600817
Deighton et al (1992) Characterization of the beta adrenoceptor subtype(s) mediating the positive inotropic effects of epinine, DA, dobutamine, denopamine and xamoterol in isolated human right atrium. J.Pharmacol.Exp.Ther. 262 532 PMID: 1354251
Merck Index 12 3456
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Keywords: Dobutamine hydrochloride, Dobutamine hydrochloride supplier, α1-adrenoceptor, alpha1-adrenoceptors, a1-adrenoceptors, β1-adrenoceptors, beta1-adrenoceptors, β2-adrenoceptors, α2-adrenoceptor, beta2-adrenoceptors, b1-adrenoceptors, b2-adrenoceptors, agonists, β1-Adrenergic, beta1-Adrenergic, b1-adrenergi, Non-selective, Adrenergic, Beta, Receptors, 0515, Tocris Bioscience
3 Citations for Dobutamine hydrochloride
Citations are publications that use Tocris products. Selected citations for Dobutamine hydrochloride include:
Skeberdis et al (1997) Pharmacological characterization of the receptors involved in the beta-adrenoceptor-mediated stimulation of the L-type Ca2+ current in frog ventricular myocytes. Br J Pharmacol 121 1277 PMID: 9257904
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Biol Reprod 329 350 PMID: 19144685
Li et al (2017) Pericytes impair capillary blood flow and motor function after chronic spinal cord injury. Nat Med 23 733 PMID: 28459438
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.