DMPQ dihydrochloride

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Description: Potent, selective inhibitor of PDGFRβ
Chemical Name: 5,7-Dimethoxy-3-(4-pyridinyl)quinoline dihydrochloride
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for DMPQ dihydrochloride

DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM). Displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C.

Technical Data for DMPQ dihydrochloride

M. Wt 339.22
Formula C16H14N2O2.2HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1123491-15-5
PubChem ID 45073427
Smiles COC1=CC(OC)=C2C(N=CC(C3=CC=NC=C3)=C2)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DMPQ dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 100

Preparing Stock Solutions for DMPQ dihydrochloride

The following data is based on the product molecular weight 339.22. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.74 mL 29.48 mL
5 mM 0.59 mL 2.95 mL 5.9 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets for DMPQ dihydrochloride

References for DMPQ dihydrochloride

References are publications that support the biological activity of the product.

Dolle et al (1994) 5,7-Dimethoxy-3-(4-pyridinyl)quinoline is a potent and selective inhibitor of human vascular β-type platelet-derived growth factor receptor tyrosine kinase J.Med.Chem. 37 2627 PMID: 8064792

If you know of a relevant reference for DMPQ dihydrochloride, please let us know.

View Related Products by Product Action

View all PDGFR Inhibitors

Keywords: DMPQ dihydrochloride, DMPQ dihydrochloride supplier, Potent, selective, inhibitors, inhibits, PDGFRβ, PDGFRbeta, PDGFRb, Platelet, Derived, Growth, Factors, Receptors, Receptor, Tyrosine, Kinases, RTKs, PDGFR, 1222, Tocris Bioscience

1 Citation for DMPQ dihydrochloride

Citations are publications that use Tocris products. Selected citations for DMPQ dihydrochloride include:

Srinivasan (2018) Substrate stiffness modulates the multipotency of human neural crest derived ectomesenchymalstem cells via CD44 mediated PDGFR signaling. Biomaterials 167 153 PMID: 29571051

Do you know of a great paper that uses DMPQ dihydrochloride from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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