DMH4

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Cat.No. 4471 - DMH4 | C24H24N4O2 | CAS No. 515880-75-8
Description: Selective VEGFR-2 inhibitor
Chemical Name: 6-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-3-phenylpyrazolo[1,5-a]pyrimidine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)
Pathways (1)

Biological Activity

Selective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I respectively). Displays antiangiogenic activity in vitro and in vivo.

Compound Libraries

DMH4 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 400.47
Formula C24H24N4O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 515880-75-8
PubChem ID 5329447
InChI Key SKZQZGSPYYHTQG-UHFFFAOYSA-N
Smiles C(C=N2)(C4=CC=C(OCCN5CCOCC5)C=C4)=CN1C2=C(C3=CC=CC=C3)C=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.02 50

Preparing Stock Solutions

The following data is based on the product molecular weight 400.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.99 mL 24.97 mL 49.94 mL
2.5 mM 1 mL 4.99 mL 9.99 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
25 mM 0.1 mL 0.5 mL 1 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References

References are publications that support the biological activity of the product.

Fraley et al (2002) Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics. Bioorg.Med.Chem.Lett. 12 3537 PMID: 12443771

Hao et al (2010) In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem.Biol. 5 245 PMID: 20020776


If you know of a relevant reference for DMH4, please let us know.

View Related Products by Product Action

View all VEGFR Inhibitors

Keywords: DMH4, DMH4 supplier, VEGFR-2, inhibitors, inhibits, dorsomorphin, vascular, endothelial, growth, factor, receptor-2, KDR, VEGFR, 4471, Tocris Bioscience

1 Citation for DMH4

Citations are publications that use Tocris products. Selected citations for DMH4 include:

Lee et al (2017) Carbohydrate-binding protein CLEC14A regulates VEGFR-2- and VEGFR-3-dependent signals during angiogenesis and lymphangiogenesis. J Clin Invest 127 457 PMID: 27991863


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Reviews for DMH4

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for DMH4

VEGF

VEGF Signaling Pathway

VEGF signaling pathway is involved in embryonic vascular development (vasculogenesis) and in the formation of new blood vessel (angiogenesis). It also induces cell migration, proliferation and survival.