DMAB-anabaseine dihydrochloride

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Cat.No. 2241 - DMAB-anabaseine dihydrochloride | C19H21N3.2HCl | CAS No. 154149-38-9
Description: Partial agonist at α7 nAChR; also α4β2 antagonist
Chemical Name: 4-[(5,6-Dihydro[2,3'-bipyridin]-3(4H)-ylidene)methyl]-N,N-dimethylbenzenamine dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Partial agonist at α7-containing neuronal nicotinic receptors and antagonist at α4β2 and other nicotinic receptors. Displays specific cognition-enhancing effects; improves long-term memory in rats.

Compound Libraries

DMAB-anabaseine dihydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 364.32
Formula C19H21N3.2HCl
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 154149-38-9
PubChem ID 16759167
InChI Key DHCNEWWWKHBASC-YNHPUKFJSA-N
Smiles CN(C)C1=CC=C(/C=C2/C(C3=CN=CC=C3)=NCCC2)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 9.11 25
water 36.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 364.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.72 mL 27.45 mL
5 mM 0.55 mL 2.74 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Arendash et al (1995) Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21. Brain Res. 674 252 PMID: 7796104

Kem et al (1997) Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J.Pharmacol.Exp.Ther. 283 979 PMID: 9399967

Stevens et al (1998) Selective alpha7-nicotinic agonists normalize inhibition of auditory response in DBA mice. Psychopharmacology 136 320 PMID: 9600576


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Citations for DMAB-anabaseine dihydrochloride

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