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Selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro. Induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose. Exhibits antidiabetic effects.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 621.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.61 mL||8.04 mL||16.08 mL|
|5 mM||0.32 mL||1.61 mL||3.22 mL|
|10 mM||0.16 mL||0.8 mL||1.61 mL|
|50 mM||0.03 mL||0.16 mL||0.32 mL|
References are publications that support the biological activity of the product.
Lee et al (2011) A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474 506 PMID: 21614002
If you know of a relevant reference for DLPC, please let us know.
Keywords: DLPC, DLPC supplier, Dilauroyl, phosphatidylcholine, LRH-1, agonist, orphan, nuclear, receptor, agonists, NR5A2, saturated, fatty, acid, chain, liver, homolog, homologue, Other, Nuclear, Receptors, Lipid, Metabolism, 4378, Tocris Bioscience
2 Citations for DLPC
Citations are publications that use Tocris products. Selected citations for DLPC include:
Zhu et al (2014) Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature 508 93 PMID: 24572354
Zimmerlin et al (2016) Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality. Development 143 4368 PMID: 27660325
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