DLPC

Pricing Availability Delivery Time Qty
Cat.No. 4378 - DLPC | C32H64NO8P | CAS No. 18194-25-7
Description: LRH-1 agonist; regulates bile acid metabolism
Chemical Name: (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxododecyl)oxy]-3,5,9-trioxa-4-phosphaheneicosan-1-aminium-4-oxide
Datasheet
Citations (1)
Literature

Biological Activity

Selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro. Induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose. Exhibits antidiabetic effects.

Technical Data

M. Wt 621.83
Formula C32H64NO8P
Storage Store at -20°C
CAS Number 18194-25-7
PubChem ID 512874
InChI Key IJFVSSZAOYLHEE-SSEXGKCCSA-N
Smiles [O-]P(OC[C@H](OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)(OCC[N+](C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 62.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 621.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.61 mL 8.04 mL 16.08 mL
5 mM 0.32 mL 1.61 mL 3.22 mL
10 mM 0.16 mL 0.8 mL 1.61 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lee et al (2011) A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474 506 PMID: 21614002


If you know of a relevant reference for DLPC, please let us know.

Keywords: Dilauroyl phosphatidylcholine LRH-1 agonist orphan nuclear receptor agonists NR5A2 saturated fatty acid chain liver receptor homolog homologue Other Lipid Metabolism

1 Citation for DLPC

Citations are publications that use Tocris products. Selected citations for DLPC include:

Zhu et al (2014) Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature 508 93 PMID: 24572354


Do you know of a great paper that uses DLPC from Tocris? If so please let us know.

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Reviews

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Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for DLPC

Protocols

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