DLPC

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Cat.No. 4378 - DLPC | C32H64NO8P | CAS No. 18194-25-7
Description: LRH-1 agonist; regulates bile acid metabolism
Chemical Name: (7R)-4-Hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxododecyl)oxy]-3,5,9-trioxa-4-phosphaheneicosan-1-aminium-4-oxide
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro. Induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose. Exhibits antidiabetic effects.

Technical Data

M. Wt 621.83
Formula C32H64NO8P
Storage Store at -20°C
CAS Number 18194-25-7
PubChem ID 512874
InChI Key IJFVSSZAOYLHEE-SSEXGKCCSA-N
Smiles [O-]P(OC[C@H](OC(CCCCCCCCCCC)=O)COC(CCCCCCCCCCC)=O)(OCC[N+](C)(C)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 62.18 100

Preparing Stock Solutions

The following data is based on the product molecular weight 621.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.61 mL 8.04 mL 16.08 mL
5 mM 0.32 mL 1.61 mL 3.22 mL
10 mM 0.16 mL 0.8 mL 1.61 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Lee et al (2011) A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474 506 PMID: 21614002


If you know of a relevant reference for DLPC, please let us know.

Keywords: DLPC, DLPC supplier, Dilauroyl, phosphatidylcholine, LRH-1, agonist, orphan, nuclear, receptor, agonists, NR5A2, saturated, fatty, acid, chain, liver, homolog, homologue, Other, Nuclear, Receptors, Lipid, Metabolism, 4378, Tocris Bioscience

1 Citation for DLPC

Citations are publications that use Tocris products. Selected citations for DLPC include:

Zhu et al (2014) Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature 508 93 PMID: 24572354


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Literature in this Area

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New Product Guide (Spring/Summer 2018)

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