(±)-threo-3-Methylglutamic acid

Pricing Availability   Qty
Cat.No. 0811 - (±)-threo-3-Methylglutamic acid | C6H11NO4 | CAS No. 63088-04-0
Description: EAAT2 and EAAT4 blocker
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

A potent blocker of glutamate transport; selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively).

Technical Data

M. Wt 161.16
Formula C6H11NO4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 63088-04-0
PubChem ID 90479741
InChI Key GZKDJYLZHGMSFM-KSTNSCRMSA-N
Smiles N[C@@]([C@@]([H])(C)CC(O)=O)([H])C(O)=O.[H][C@](CC(O)=O)(C)[C@@](N)([H])C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in 1eq. NaOH

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Eliasof et al (2001) Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J.Neurochem. 77 550 PMID: 11299317

Mitrovic et al (1998) Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. J.Biol.Chem. 273 14698 PMID: 9614067

Vandenberg et al (1997) Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol.Pharmacol. 51 809 PMID: 9145919


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Keywords: (±)-threo-3-Methylglutamic acid, (±)-threo-3-Methylglutamic acid supplier, EAAT2, EAAT4, blockers, Excitatory, Amino, Acid, Transporters, GLT-1, Glutamate, Monoamine, Neurotransmitter, 0811, Tocris Bioscience

1 Citation for (±)-threo-3-Methylglutamic acid

Citations are publications that use Tocris products. Selected citations for (±)-threo-3-Methylglutamic acid include:

Jarzylo and Man (2012) Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci 32 2552 PMID: 22396428


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Literature in this Area

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