(±)-PPCC oxalate

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Cat.No. 3870 - (±)-PPCC oxalate | C24H29NO3.C2H2O4 | CAS No. 932736-91-9
Description: Selective sigma (σ) agonist (σ1> σ2)
Chemical Name: (S*,R*)-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.

Technical Data

M. Wt 469.53
Formula C24H29NO3.C2H2O4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 932736-91-9
PubChem ID 90488889
Smiles CC(C=C3)=CC=C3[C@@]1(C(OC)=O)C[C@@H]1CN2CCC(C4=CC=CC=C4)(O)CC2.CC(C=C7)=CC=C7[C@]5([C@](OC)=O)C[C@H]5CN6CCC(C8=CC=CC=C8)(O)CC6.O=C(O)C(O)=O.O=C(O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.95 100
ethanol 4.7 10

Preparing Stock Solutions

The following data is based on the product molecular weight 469.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.65 mL 21.3 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Prezzavento et al (2007) Novel sigma receptor ligands: synthesis and biological profile. J.Med.Chem. 50 951 PMID: 17328523

Prezzavento et al (2008) A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect. Life Sci. 82 549 PMID: 18261749

Antonini et al (2009) Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J.Neurochem. 109 744 PMID: 19245662

If you know of a relevant reference for (±)-PPCC oxalate, please let us know.

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Keywords: selective sigma receptor agonists ligand sigma2 sigma1 Sigma1 Receptors

1 Citation for (±)-PPCC oxalate

Citations are publications that use Tocris products. Selected citations for (±)-PPCC oxalate include:

Malik et al (2015) The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. J Biol Chem 172 2519 PMID: 25573298

Do you know of a great paper that uses (±)-PPCC oxalate from Tocris? If so please let us know.

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Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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