±-MF 094

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Description: Selective USP30 inhibitor
Chemical Name: N-(1-((5-(N-(tert-Butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclohexanecarboxamide
Purity: ≥98% (HPLC)

Biological Activity for ±-MF 094

±-MF 904 is the racemate of MF 904, the S-enantiomer. The S-enantiomer is a selective USP30 (ubiquitin-specific-processing protease 30) inhibitor (IC50 = 120 nM). MF 094 increases protein ubiquitination and accelerates mitophagy.

Technical Data for ±-MF 094

M. Wt 535.7
Formula C30H37N3O4S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2758431-95-5
PubChem ID 146503417
Smiles CC(C)(NS(=O)(C1=CC=CC2=C1C=CC=C2NC(C(NC(C3CCCCC3)=O)CC4=CC=CC=C4)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ±-MF 094

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 26.78 50

Preparing Stock Solutions for ±-MF 094

The following data is based on the product molecular weight 535.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.73 mL 18.67 mL 37.33 mL
2.5 mM 0.75 mL 3.73 mL 7.47 mL
5 mM 0.37 mL 1.87 mL 3.73 mL
25 mM 0.07 mL 0.37 mL 0.75 mL

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References for ±-MF 094

References are publications that support the biological activity of the product.

Kluge et al (2018) Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg.Med.Chem.Lett. 28 2655 PMID: 29935771

Li and Liu et al (2020) Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors. Eur.J.Med.Chem. 191 112107 PMID: 32092586

If you know of a relevant reference for ±-MF 094, please let us know.

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Keywords: (±)-MF 094, (±)-MF 094 supplier, MF094, racemate, USP30, inhibitors, inhibits, selective, ubiquitin, carboxyl-terminal, hydrolase, specific-processing, protease, mitophagy, ubiquitination, Deubiquitinating, Enzymes, 6718, Tocris Bioscience

Citations for ±-MF 094

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