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±-MF 904 is the racemate of MF 904, the S-enantiomer. The S-enantiomer is a selective USP30 (ubiquitin-specific-processing protease 30) inhibitor (IC50 = 120 nM). MF 094 increases protein ubiquitination and accelerates mitophagy.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 535.7. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.73 mL||18.67 mL||37.33 mL|
|2.5 mM||0.75 mL||3.73 mL||7.47 mL|
|5 mM||0.37 mL||1.87 mL||3.73 mL|
|25 mM||0.07 mL||0.37 mL||0.75 mL|
References are publications that support the biological activity of the product.
Kluge et al (2018) Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg.Med.Chem.Lett. 28 2655 PMID: 29935771
Li and Liu et al (2020) Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors. Eur.J.Med.Chem. 191 112107 PMID: 32092586
If you know of a relevant reference for ±-MF 094, please let us know.
Keywords: (±)-MF 094, (±)-MF 094 supplier, MF094, racemate, USP30, inhibitors, inhibits, selective, ubiquitin, carboxyl-terminal, hydrolase, specific-processing, protease, mitophagy, ubiquitination, Deubiquitinating, Enzymes, 6718, Tocris Bioscience
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