(±)-AC 7954 hydrochloride

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Cat.No. 2484 - (±)-AC 7954 hydrochloride | C19H20ClNO2.HCl | CAS No. 477313-09-0
Description: Non-peptide UT receptor agonist
Chemical Name: (±)-3-(4-Chlorophenyl)-3-[2-(dimethylamino)ethyl]-3,4-dihydro-1H-2-benzopyran-1-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Highly selective, non-peptide urotensin-II (UT) receptor agonist that displays potent activity at human and rat UT receptors (pEC50 values are 6.5 and 6.7 respectively).

Compound Libraries

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Technical Data

M. Wt 366.28
Formula C19H20ClNO2.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 477313-09-0
PubChem ID 9907171
InChI Key AJPGLOWFIBOGMH-UHFFFAOYSA-N
Smiles Cl.CN(C)CCC1(CC2=CC=CC=C2C(=O)O1)C1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.47 75
water 27.47 75

Preparing Stock Solutions

The following data is based on the product molecular weight 366.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 3.64 mL 18.2 mL 36.4 mL
3.75 mM 0.73 mL 3.64 mL 7.28 mL
7.5 mM 0.36 mL 1.82 mL 3.64 mL
37.5 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Croston et al (2002) Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954). J.Med.Chem. 45 4950 PMID: 12408704

Lavecchia et al (2005) Architecture of the human urotensin II receptor: comparison of the binding domains of peptide and non-peptide urotensin II agonists. J.Med.Chem. 48 2480 PMID: 15801838

Lehmann et al (2006) Novel potent and efficacious nonpeptidic urotensin II receptor agonists. J.Med.Chem. 49 2232 PMID: 16570919


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Citations for (±)-AC 7954 hydrochloride

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Literature in this Area

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